Evidence map›Paper›PMID 34668435›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2022

Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells.

Rita M Ryan, Manjeet K Paintlia, Danforth A Newton, Demetri D Spyropoulos, Matthew Kemp, Alan H Jobe, John E Baatz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Rita M RyanCase Western Reserve University, UH Rainbow Babies and Children's Hospital, Cleveland, Ohio.ORCID 0000-0002-4588-3412
Manjeet K PaintliaDarby Children's Research Institute, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina.
Danforth A NewtonDarby Children's Research Institute, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina.
Demetri D SpyropoulosDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina.
Matthew KempDepartment of Obstetrics and Gynaecology, University of Western Australia, Perth, Western Australia, Australia.
Alan H JobeCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
John E BaatzDarby Children's Research Institute, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina.
Medical University of South Carolina · USCincinnati Children's Hospital Medical Center · USNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial natriuretic peptide (ANP) and its receptors natriuretic peptide receptor (NPR)-A and NPR-C are all highly expressed in alveolar epithelial type II cells (AEC2s) in the late-gestation ovine fetal lung and are dramatically decreased postnatally. However, of all the components, NPR-C stimulation inhibits ANP-mediated surfactant secretion. Since alveolar oxygen increases dramatically after birth, and steroids are administered to mothers antenatally to enhance surfactant lung maturity, we investigated the effects of O

Indexed as

AdultAlveolar Epithelial CellsAnimalsAtrial Natriuretic FactorBetamethasoneBody FluidsCell LineDexamethasoneGlucocorticoidsHumansLungMiceModels, BiologicalOxygenPulmonary SurfactantsReceptors, Atrial Natriuretic FactorAtrial Natriuretic Factoratrial natriuretic factor receptor CBetamethasoneDexamethasoneGlucocorticoidsOxygenPulmonary SurfactantsReceptors, Atrial Natriuretic FactorRNA, MessengerRNA, Small InterferingSteroidsTerbutalineatrial natriuretic peptidenatriuretic peptide receptor-Cneonatal lung biologyoxygensurfactant protein-B

Identifiers

PMID34668435
PMCPMC8721905
OpenAlexW3206454269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.