Evidence map›Paper›PMID 34668339›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Accelerated Electron Transfer in Nanostructured Electrodes Improves the Sensitivity of Electrochemical Biosensors.

Kaiyu Fu, Ji-Won Seo, Vladimir Kesler, Nicolo Maganzini, Brandon D Wilson, Michael Eisenstein, Boris Murmann, H Tom Soh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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  19. Wearable Electrochemical Biosensors for Advanced Healthcare Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaiyu FuDepartment of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA.
Ji-Won SeoDepartment of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA.
Vladimir KeslerDepartment of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA.
Nicolo MaganziniDepartment of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA.
Brandon D WilsonDepartment of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA.
Michael EisensteinDepartment of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA.
Boris MurmannDepartment of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA.
H Tom SohDepartment of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0001-9432-4011

Funding

Real-time biosensor for mapping the function of the pancreasOT2OD025342 · OD · STANFORD UNIVERSITY · PI SOH, HYONGSOK TOM · 2018 to 2021
$4.6M
BARDA 75A50119C00051Biomedical Advanced Research and Development AgencyChan-Zuckerberg BiohubNIH HHS OT2 OD025342NIH HHS OT2OD025342NIH Office of the Director OT2OD025342
6 · The paper itself

Abstract

Electrochemical biosensors hold the exciting potential to integrate molecular detection with signal processing and wireless communication in a miniaturized, low-cost system. However, as electrochemical biosensors are miniaturized to the micrometer scale, their signal-to-noise ratio degrades and reduces their utility for molecular diagnostics. Studies have reported that nanostructured electrodes can improve electrochemical biosensor signals, but since the underlying mechanism remains poorly understood, it remains difficult to fully exploit this phenomenon to improve biosensor performance. In this work, electrochemical aptamer biosensors on nanoporous electrode are optimized to achieve improved sensitivity by tuning pore size, probe density, and electrochemical measurement parameters. Further, a novel mechanism in which electron transfer is physically accelerated within nanostructured electrodes due to reduced charge screening, resulting in enhanced sensitivity is proposed and experimentally validated. In concert with the increased surface areas achieved with this platform, this newly identified effect can yield an up to 24-fold increase in signal level and nearly fourfold lower limit of detection relative to planar electrodes with the same footprint. Importantly, this strategy can be generalized to virtually any electrochemical aptamer sensor, enabling sensitive detection in applications where miniaturization is a necessity, and should likewise prove broadly applicable for improving electrochemical biosensor performance in general.

Indexed as

ElectrodesBiosensing TechniquesElectrochemical TechniquesElectronsElectron TransportEquipment DesignMetal NanoparticlesMiniaturizationaptamerbiosensorselectrochemical sensorselectron transfernanopores

Identifiers

PMID34668339
PMCPMC8655170

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.