Evidence map›Paper›PMID 34668336›Full record

ArticlePediatric obesity2022

Visceral fat and arterial stiffness in youth with healthy weight, obesity, and type 2 diabetes.

Simon Higgins, Babette S Zemel, Philip R Khoury, Elaine M Urbina, Joseph M Kindler

Open access · greenAbstract read
In one paragraph

Article in Pediatric obesity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Simon HigginsDepartment of Exercise Science, Elon University, Elon, North Carolina, USA.ORCID 0000-0001-8554-3116
Babette S ZemelDivision of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Philip R KhouryPreventive Cardiology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Elaine M UrbinaPreventive Cardiology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Joseph M KindlerDepartment of Nutritional Sciences, University of Georgia, Athens, Georgia, USA.
Cincinnati Children's Hospital Medical Center · USChildren's Hospital of Philadelphia · USElon University · USUniversity of Georgia · US

Funding

CV Disease in Adolescents with Type 2 DiabetesR01HL076269 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KIMBALL, THOMAS R · 2005 to 2008
$2.7M
NHLBI NIH HHS R01 HL076269
6 · The paper itself

Abstract

BACKGROUND AND

objectivesVisceral fat is associated with increased cardiovascular risk in adults, but studies in youth are limited. We assessed associations between visceral fat and arterial stiffness in youth with healthy weight, obesity and type 2 diabetes and determined whether relationships were independent of clinical estimates of body fatness.

methodsThis cross-sectional sample included youth ages 10-23 years (67% female, 56% non-black) with healthy weight (body mass index [BMI] = 5th-85th percentile, n = 236), obesity (BMI ≥ 95th percentile, n = 224) and type 2 diabetes (BMI ≥ 95th percentile, n = 145). Visceral fat was assessed via dual-energy X-ray absorptiometry. Carotid-femoral pulse wave velocity (PWV) was assessed via applanation tonometry. Obesity and type 2 diabetes groups were combined for final analyses. Analyses accounted for age, sex, ancestry and mean arterial pressure.

resultsVisceral fat and PWV were greater in youth with obesity versus healthy weight (p < 0.001). In youth with obesity, but not healthy weight, visceral fat was positively associated with PWV (p < 0.001) and was predictive of PWV beyond BMI and waist circumference.

conclusionsVisceral fat likely contributes to subclinical cardiovascular complications in youth. Since cardiovascular health tracks from adolescence to adulthood, longitudinal studies in youth with obesity are required to define the role of visceral fat in lifelong cardiovascular disease risk.

Indexed as

Diabetes Mellitus, Type 2Vascular StiffnessAdolescentAdultBody Mass IndexChildCross-Sectional StudiesFemaleHumansIntra-Abdominal FatMaleObesityPulse Wave AnalysisRisk FactorsYoung Adultarterial stiffnessobesitytype 2 diabetesvisceral fatyouth

Identifiers

PMID34668336
PMCPMC8923972
OpenAlexW3205040161

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.