Evidence map›Paper›PMID 34668249›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2021

Nanotechnology Enables Novel Modalities for Neuromodulation.

Xiao Yang, Eve McGlynn, Rupam Das, Sergiu P Paşca, Bianxiao Cui, Hadi Heidari

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Microfabrication Technologies for Nanoinvasive and High-Resolution Magnetic Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Perspectives on Multiscale Colloid-Based Materials for Biomedical Applications.Langmuir : the ACS journal of surfaces and colloids · 2023
    Review
  15. Review
  16. Review
  17. Review
  18. Cleanroom strategies for micro- and nano-fabricating flexible implantable neural electronics.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022
    Article
  19. Soft integration of a neural cells network and bionic interfaces.Frontiers in bioengineering and biotechnology · 2022
    Review
  20. Editorial: Optimization strategies for pain management with neuromodulation.Frontiers in pain research (Lausanne, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiao YangDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
Eve McGlynnMicroelectronics Lab (meLAB), James Watt School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK.
Rupam DasMicroelectronics Lab (meLAB), James Watt School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK.
Sergiu P PaşcaDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
Bianxiao CuiWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, 94305, USA.
Hadi HeidariMicroelectronics Lab (meLAB), James Watt School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK.ORCID https://orcid.org/0000-0001-8412-8164

Funding

Nanoscale probes for sensing molecular functions in live cellsR35GM141598 · NIGMS · STANFORD UNIVERSITY · PI CUI, BIANXIAO · 2021 to 2025
$3.4M
Developing nanoscale electrophysiology sensors for robust intracellular recordingR01GM125737 · NIGMS · STANFORD UNIVERSITY · PI CUI, BIANXIAO · 2017 to 2020
$1.4M
EPSRC 2279645European Union's Horizon 824164NIGMS NIH HHS R01 GM125737NIGMS NIH HHS R35 GM141598
6 · The paper itself

Abstract

Neuromodulation is of great importance both as a fundamental neuroscience research tool for analyzing and understanding the brain function, and as a therapeutic avenue for treating brain disorders. Here, an overview of conceptual and technical progress in developing neuromodulation strategies is provided, and it is suggested that recent advances in nanotechnology are enabling novel neuromodulation modalities with less invasiveness, improved biointerfaces, deeper penetration, and higher spatiotemporal precision. The use of nanotechnology and the employment of versatile nanomaterials and nanoscale devices with tailored physical properties have led to considerable research progress. To conclude, an outlook discussing current challenges and future directions for next-generation neuromodulation modalities is presented.

Indexed as

NanostructuresNanotechnologyNeurotransmitter AgentsAnimalsBrainBrain ChemistryHumansMagneticsNeurotransmitter Agentsnanomaterialsnanotechnologyneural interfacesneuromodulation

Identifiers

PMID34668249
PMCPMC8712412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.