Evidence map›Paper›PMID 34668064›Full record

ArticlePediatric nephrology (Berlin, Germany)2022

Anticoagulation in patients with acute kidney injury undergoing kidney replacement therapy.

Rupesh Raina, Ronith Chakraborty, Andrew Davenport, Patrick Brophy, Sidharth Sethi, Mignon McCulloch, Timothy Bunchman, Hui Kim Yap

Abstract read
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 5 countries.

Rupesh RainaAkron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, OH, USA. rraina@akronchildrens.org.ORCID 0000-0003-3892-8376
Ronith ChakrabortyAkron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, OH, USA.
Andrew DavenportUCL Department of Nephrology, Royal Free Hospital, University College London, London, UK.
Patrick BrophyDivision of Nephrology, Golisano Children's Hospital, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Sidharth SethiPediatric Nephrology, Kidney Institute, Medanta, The Medicity Hospital, Gurgaon, Haryana, India.
Mignon McCullochRed Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Timothy BunchmanPediatric Nephrology & Transplantation, Children's Hospital of Richmond at VCU, Richmond, VA, USA.
Hui Kim YapDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Cleveland Clinic · USChildren's Hospital of Richmond at VCU · USGolisano Children's Hospital · USMedanta The Medicity · INNational University of Singapore · SGThe Royal Free Hospital · GBUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney replacement therapy (KRT) is used to provide supportive therapy for critically ill patients with severe acute kidney injury and various other non-renal indications. Modalities of KRT include continuous KRT (CKRT), intermittent hemodialysis (HD), and sustained low efficiency daily dialysis (SLED). However, circuit clotting is a major complication that has been investigated extensively. Extracorporeal circuit clotting can cause reduction in solute clearances and can cause blood loss, leading to an upsurge in treatment costs and a rise in workload intensity. In this educational review, we discuss the pathophysiology of the clotting cascade within an extracorporeal circuit and the use of various types of anticoagulant methods in various pediatric KRT modalities.

Indexed as

Acute Kidney InjuryContinuous Renal Replacement TherapyAnticoagulantsBlood CoagulationChildCritical IllnessHeparinHumansRenal DialysisRenal Replacement TherapyAnticoagulantsHeparinAnticoagulationArgatrobanCitrateHeparinHirudinKidney replacement therapyProstacyclin

Identifiers

PMID34668064
OpenAlexW3207663294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.