Evidence map›Paper›PMID 34667958›Full record

ArticleHeart rhythm O22021

Left ventricular activation time and pattern are preserved with both selective and nonselective His bundle pacing.

Ahran D Arnold, Matthew J Shun-Shin, Nadine Ali, Daniel Keene, James P Howard, Ji-Jian Chow, Norman A Qureshi, Michael Koa-Wing, Mark Tanner, David C Lefroy and 7 more

Open access · goldAbstract read
In one paragraph

Article in Heart rhythm O2, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Implant, assessment, and management of conduction system pacing.European heart journal supplements : journal of the European Society of Cardiology · 2023
    Article
  5. Left bundle branch pacing with and without anodal capture: impact on ventricular activation pattern and acute haemodynamics.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  6. Cardiac Resynchronisation with Conduction System Pacing.Arrhythmia & electrophysiology review · 2023
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Ahran D ArnoldNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Matthew J Shun-ShinNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Nadine AliNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Daniel KeeneNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
James P HowardNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Ji-Jian ChowNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Norman A QureshiNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Michael Koa-WingNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Mark TannerNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
David C LefroyNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Nick W F LintonNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Fu Siong NgNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Phang Boon LimNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Nicholas S PetersNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Prapa KanagaratnamNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Darrel P FrancisNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Zachary I WhinnettNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Imperial College London · GB

Funding

British Heart Foundation FS/13/44/30291British Heart Foundation FS/19/4/34013British Heart Foundation FS/CRTF/21/24171British Heart Foundation RG/16/3/32175
6 · The paper itself

Abstract

backgroundHis bundle pacing (HBP) can be achieved in 2 ways: selective HBP (S-HBP), where the His bundle is captured alone, and nonselective HBP (NS-HBP), where local myocardium is also captured, resulting a pre-excited electrocardiogram appearance.

objectiveWe assessed the impact of this ventricular pre-excitation on left and right ventricular dyssynchrony.

methodsWe recruited patients who displayed both S-HBP and NS-HBP. We performed noninvasive epicardial electrical mapping for left and right ventricular activation time (LVAT and RVAT) and pattern.

resultsTwenty patients were recruited. In the primary analysis, the mean within-patient change in LVAT from S-HBP to NS-HBP was -5.5 ms (95% confidence interval: -0.6 to -10.4, noninferiority

conclusionCompared to S-HBP, local myocardial capture during NS-HBP produces pre-excitation of the basal right ventricle resulting in QRS duration prolongation. However, NS-HBP preserves the left ventricular activation time and pattern of S-HBP. Left ventricular dyssynchrony is not an important factor when choosing between S-HBP and NS-HBP in most patients.

Indexed as

Conduction system pacingECGElectrocardiographic imagingHis bundle pacingPacingSelective His bundle pacing

Identifiers

PMID34667958
PMCPMC8505200
OpenAlexW3192866991

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.