Evidence map›Paper›PMID 34667856›Full record

ArticleLaryngoscope investigative otolaryngology2021

Normative data for ages 18-45 for ocular motor and vestibular testing using eye tracking.

Aura Kullmann, Robin C Ashmore, Alexandr Braverman, Christian Mazur, Hillary Snapp, Erin Williams, Mikhaylo Szczupak, Sara Murphy, Kathryn Marshall, James Crawford and 3 more

Abstract read
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Aura KullmannNeurolign USA LLC, A Subsidiary of Neurolign Technologies Inc. (formerly Neuro Kinetics, Inc.) Pittsburgh Pennsylvania USA.ORCID https://orcid.org/0000-0001-6625-2946
Robin C AshmoreNeurolign USA LLC, A Subsidiary of Neurolign Technologies Inc. (formerly Neuro Kinetics, Inc.) Pittsburgh Pennsylvania USA.
Alexandr BravermanThe Hebrew University of Jerusalem Jerusalem Israel.
Christian MazurNeurolign USA LLC, A Subsidiary of Neurolign Technologies Inc. (formerly Neuro Kinetics, Inc.) Pittsburgh Pennsylvania USA.
Hillary SnappDepartment of Otolaryngology Miller School of Medicine, University of Miami Miami Florida USA.ORCID https://orcid.org/0000-0002-2000-5357
Erin WilliamsDepartment of Otolaryngology Miller School of Medicine, University of Miami Miami Florida USA.
Mikhaylo SzczupakDepartment of Otolaryngology Miller School of Medicine, University of Miami Miami Florida USA.
Sara MurphyNaval Medical Center San Diego California USA.
Kathryn MarshallDepartment of Defense Hearing Center of Excellence San Antonio Texas USA.
James CrawfordMadigan Army Medical Center Tacoma Washington USA.ORCID https://orcid.org/0000-0001-7599-647X
Carey D BalabanDepartment of Otolaryngology University of Pittsburgh Pittsburgh Pennsylvania USA.ORCID https://orcid.org/0000-0002-3570-3844
Michael HofferDepartment of Otolaryngology Miller School of Medicine, University of Miami Miami Florida USA.ORCID https://orcid.org/0000-0002-5574-4387
Alexander KidermanNeurolign USA LLC, A Subsidiary of Neurolign Technologies Inc. (formerly Neuro Kinetics, Inc.) Pittsburgh Pennsylvania USA.

Funding

Development of a pediatric oculomotor and vestibular normative database as an essential tool for objective evaluation of concussion and return-to-school/playR44HD100247 · NICHD · NEUROLIGN USA, LLC · PI HOFFER, MICHAEL E., KIDERMAN, ALEXANDER D · 2019 to 2019
$225k
Computerized Rotational Head Impulse Test-Vertical (crHIT-vertical)R43DC014611 · NIDCD · NEUROLIGN USA, LLC · PI KIDERMAN, ALEXANDER D · 2015 to 2015
$150k
NICHD NIH HHS R44 HD100247NIDCD NIH HHS R43 DC014611
6 · The paper itself

Abstract

objectiveEye tracking technology has been employed in assessing ocular motor and vestibular function following vestibular and neurologic conditions, including traumatic brain injury (TBI). Assessments include tests that provide visual and motion (rotation) stimuli while recording horizontal, vertical, and torsional eye movements. While some of these tests have shown diagnostic promise in previous studies, their use in clinical practice is limited by the lack of normative data. The goal of this study was to construct normative reference ranges to be used when comparing patients' results.

methodsOptokinetic response, subjective visual horizontal and vertical, and rotation tests were administered to male and female volunteers, ages 18-45, who were free from neurological, vestibular disorders, or other head injuries. Tests were administered using either a rotatory chair or a portable virtual reality-like goggle equipped with video-oculography.

resultsReference values for eye movements in response to different patterns of stimuli were analyzed from 290 to 449 participants. Analysis of gender (self-reported) or age when grouped as pediatric (late adolescent; 18-21 years of age) and adult (21-45 years of age) revealed no effects on the test metrics. Data were pooled and presented for each test metric as the 95% reference interval (RI) with 90% confidence intervals (CI) on upper and lower limits of the RI.

conclusionsThis normative database can serve as a tool to aid in diagnosis, treatment, and/or rehabilitation protocols for vestibular and neurological conditions, including mild TBI (mTBI). This database has been cleared by the FDA for use in clinical practice (K192186). LEVEL OF EVIDENCE: 2b.

Indexed as

concussioneye trackingmild traumatic brain injurymTBINeurolign Dx 100neurological conditionsNOTCrotation testsvestibular conditions

Identifiers

PMID34667856
PMCPMC8513422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.