Evidence map›Paper›PMID 34667834›Full record

ArticleLaryngoscope investigative otolaryngology2021

Radiographic disease severity in chronic rhinosinusitis patients and health care utilization.

Mitesh P Mehta, Kevin Hur, Caroline P E Price, Stephanie Shintani-Smith, Kevin C Welch, David B Conley, Robert C Kern, Bruce K Tan

Open access · goldAbstract read
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mitesh P MehtaDepartment of Otolaryngology-Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA.ORCID https://orcid.org/0000-0002-2122-5650
Kevin HurDepartment of Otolaryngology-Head and Neck Surgery University of Southern California Los Angeles California USA.ORCID https://orcid.org/0000-0001-7016-4375
Caroline P E PriceDepartment of Otolaryngology-Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA.
Stephanie Shintani-SmithDepartment of Otolaryngology-Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA.
Kevin C WelchDepartment of Otolaryngology-Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA.
David B ConleyDepartment of Otolaryngology-Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA.
Robert C KernDepartment of Otolaryngology-Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA.
Bruce K TanDepartment of Otolaryngology-Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA.
Northwestern University · USUniversity of Southern California · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Population-based CRS epidemiology: sex differences, natural history, and long-term outcomes based on clinically-defined phenotypes and biologically-based endotypes - GeisingerP01AI145818 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KERN, ROBERT C · 2019 to 2023
$9.3M
Type-2 inflammation mediates olfactory loss in Chronic Rhinosinusitis: mechanisms and therapeutic opportunitiesR01DC016645 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TAN, BRUCE K · 2018 to 2022
$3.0M
Autoantibody mediated pathogenesis in chronic rhinosinusitis with nasal polyps: mechanisms and consequencesR01AI134952 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TAN, BRUCE K · 2018 to 2022
$2.0M
NCATS NIH HHS UL1 TR001422NIAID NIH HHS P01 AI145818NIAID NIH HHS R01 AI134952NIDCD NIH HHS R01 DC016645
6 · The paper itself

Abstract

objectivesChronic rhinosinusitis (CRS) affects approximately 12% of the population and leads to increased health care utilization and indirect costs exceeding $20 billion annually in the United States. The Lund-Mackay score (LMS) measures radiographic disease severity for CRS but poorly correlates with symptom scores. The association between LMS and health care utilization in CRS patients has not yet been investigated. The study aimed to assess the association between health care utilization and CRS radiographic severity using LMS.

methodsCRS patients enrolled in a clinical registry were evaluated. Nasal endoscopy findings and LMS were recorded for patients with sinus CT imaging. Patient symptom scores, demographic characteristics, and health care utilization measures were collected. The relationship between these factors and LMS was examined.

resultsA total of 556 patients met inclusion criteria. Mean age was 45.3 years, 53.4% were male, and 41.7% had nasal polyps. There was no difference in sex, smoking history, 22-item Sino-nasal Outcome Test scores, or past medical history factors between patients with high (≥8, n = 410) and low (<8, n = 146) LMS. Among high LMS patients, 73.7% underwent endoscopic sinus surgery (ESS) compared to 55.5% with low LMS (

conclusionCRS patients with severe radiographic disease are more likely to have nasal polyps, undergo ESS, and take fewer antibiotic courses. However, there is no association between radiographic disease severity and other measures of health care utilization. LEVEL OF EVIDENCE: 2b, individual retrospective cohort study.

Indexed as

chronic rhinosinusitishealth care utilizationLund‐Mackay scoreradiographic disease severitySNOT‐22

Identifiers

PMID34667834
PMCPMC8513440
OpenAlexW3200337661

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.