Evidence map›Paper›PMID 34667601›Full record

ArticleClinical case reports2021

A case of "smoldering" immune-mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke.

Mark E Pepin, Eyad Saca, Soo Y Kwon, Jori May

Abstract readCase Reports
In one paragraph

Article in Clinical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mark E PepinDepartment of Biomedical Engineering University of Alabama at Birmingham Birmingham AL USA.ORCID https://orcid.org/0000-0003-0114-560X
Eyad SacaDepartment of Neurology University of Alabama at Birmingham Birmingham AL USA.
Soo Y KwonDepartment of Neurology University of Alabama at Birmingham Birmingham AL USA.
Jori MayDepartment of Medicine Division of Hematology/Oncology University of Alabama at Birmingham Birmingham AL USA.ORCID https://orcid.org/0000-0001-7744-5700

Funding

GADD45B and Metabolic Memory in Diabetic Heart FailureF30HL137240 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PEPIN, MARK EMILE · 2018 to 2019
$83k
NHLBI NIH HHS F30 HL137240
6 · The paper itself

Abstract

Prompt recognition and treatment for thrombotic thrombocytopenic purpura (TTP) are critical to prevent the irreversible manifestations of this rare and quickly fatal hematologic disorder. Untreated TTP is typically a rapid-onset disease with mortality exceeding 90% within days in the absence of appropriate treatment. In the current report, we describe a case of immune-mediated TTP (iTTP) in a 62-year-old man manifesting as longstanding thrombocytopenia, recurrent cardioembolic strokes, and valvular thrombogenesis over a period of 3 years. We provide correlative evidence to support the potential contribution of adalimumab, a TNFα inhibitor, to the development of iTTP. We offer several educational insights regarding the identification of atypical presentations of iTTP owing to the longstanding disease course and numerous clinical comorbidities seen in this patient.

Indexed as

adalimumabmicroangiopathythromboembolic strokethrombotic thrombocytopenic purpura

Identifiers

PMID34667601
PMCPMC8507438

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.