ArticleChemical science2021
Broadband measurement of true transverse relaxation rates in systems with coupled protons: application to the study of conformational exchange.
Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Universally Quantitative Band-Selective Pure Shift NMR Spectroscopy.Analytical chemistry · 2024Article
- A "Steady-State" Relaxation Dispersion Nuclear Magnetic Resonance Experiment for Studies of Chemical Exchange in DegenerateThe journal of physical chemistry letters · 2022Article
- Giving Pure Shift NMR Spectroscopy a REST─Ultrahigh-Resolution Mixture Analysis.Analytical chemistry · 2022Article
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Authors and funding
6 authors.
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Abstract
Accurate measurement of transverse relaxation rates in coupled spin systems is important in the study of molecular dynamics, but is severely complicated by the signal modulations caused by scalar couplings in spin echo experiments. The most widely used experiments for measuring transverse relaxation in coupled systems, CPMG and PROJECT, can suppress such modulations, but they also both suppress some relaxation contributions, and average relaxation rates between coupled spins. Here we introduce a new experiment which for the first time allows accurate broadband measurement of transverse relaxation rates of coupled protons, and hence the determination of exchange rate constants in slow exchange from relaxation measurements. The problems encountered with existing methods are illustrated, and the use of the new method is demonstrated for the classic case of hindered amide rotation and for the more challenging problem of exchange between helical enantiomers of a gold(i) complex.
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