ArticleChemical science2021
Electrostatic regulation of blue copper sites.
Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Hydrophobic tuning with non-canonical amino acids in a copper metalloenzyme.Nature chemistry · 2026Article
- Beyond the coupled distortion model: structural analysis of the single domain cupredoxin AcoP, a green mononuclear copper centre with original features.Dalton transactions (Cambridge, England : 2003) · 2024Article
- Free Energy Profile Decomposition Analysis for QM/MM Simulations of Enzymatic Reactions.Journal of chemical theory and computation · 2023Article
- Electrochemistry in sensing of molecular interactions of proteins and their behavior in an electric field.Mikrochimica acta · 2023Review
- The structure of plastocyanin tunes the midpoint potential by restricting axial ligation of the reduced copper ion.Communications chemistry · 2023Article
- A two-directional vibrational probe reveals different electric field orientations in solution and an enzyme active site.Nature chemistry · 2022Article
- Oriented internal electrostatic fields: an emerging design element in coordination chemistry and catalysis.Chemical science · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In the last 50 years, the blue copper proteins became central targets of investigation. Extensive experiments focused on the Cu coordination to probe the effect of local perturbations on its properties. We found that local electric fields, generated by charged residues evolutionarily placed throughout the protein edifice, mainly second sphere, but also more remotely, constitute an additional significant factor regulating blue copper proteins. These fields are not random, but exhibit a highly specific directionality, negative with respect to the and vectors in the Cu first shell. The field magnitude contributes to fine-tuning of the geometric and electronic properties of Cu sites in individual blue copper proteins. Specifically, the local electric fields evidently control the Cu-S
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Registered trials
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