Evidence map›Paper›PMID 34667534›Full record

ArticleComputational and structural biotechnology journal2021

Integrative structural biology of the penicillin-binding protein-1 from

Siseth Martínez-Caballero, Kiran V Mahasenan, Choon Kim, Rafael Molina, Rhona Feltzer, Mijoon Lee, Renee Bouley, Dusan Hesek, Jed F Fisher, Inés G Muñoz and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Siseth Martínez-CaballeroDepartment of Crystallography and Structural Biology, Institute of Physical Chemistry "Rocasolano", CSIC, 28006 Madrid, Spain.
Kiran V MahasenanDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Choon KimDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Rafael MolinaDepartment of Crystallography and Structural Biology, Institute of Physical Chemistry "Rocasolano", CSIC, 28006 Madrid, Spain.
Rhona FeltzerDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Mijoon LeeDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Renee BouleyDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Dusan HesekDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Jed F FisherDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Inés G MuñozStructural Biology Programme, Spanish National Cancer Research Center (CNIO), 28029 Madrid, Spain.
Mayland ChangDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Shahriar MobasheryDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Juan A HermosoDepartment of Crystallography and Structural Biology, Institute of Physical Chemistry "Rocasolano", CSIC, 28006 Madrid, Spain.
University of Notre Dame · USInstituto de Química Física Blas Cabrera · ESSpanish National Cancer Research Centre · ES

Funding

Inducible Antibiotic Resistance in Methicillin-Resistant Staphylococcus AureusR01AI104987 · NIAID · UNIVERSITY OF NOTRE DAME · PI Shahriar Mobashery · 2013 to 2026
$7.3M
The quinazolinone class of antibacterial agentsR01AI116548 · NIAID · UNIVERSITY OF NOTRE DAME · PI CHANG, MAYLAND F · 2015 to 2019
$3.0M
NIAID NIH HHS R01 AI104987NIAID NIH HHS R01 AI116548
6 · The paper itself

Abstract

The penicillin-binding proteins are the enzyme catalysts of the critical transpeptidation crosslinking polymerization reaction of bacterial peptidoglycan synthesis and the molecular targets of the penicillin antibiotics. Here, we report a combined crystallographic, small-angle X-ray scattering (SAXS) in-solution structure, computational and biophysical analysis of PBP1 of

Indexed as

Antibiotics inhibitionDivisomeMolecular dynamics simulationsPASTA domainsPBP1Peptidoglycan bindingSAXS in-solution structureStaphylococcus aureusX-ray crystal structure

Identifiers

PMID34667534
PMCPMC8493512
OpenAlexW3199478947

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.