Evidence map›Paper›PMID 34667500›Full record

ReviewJournal of clinical and experimental dentistry2021

Effects of natural extracts in the treatment of oral ulcers: A systematic review of evidence from experimental studies in animals.

Schilin D Wen, Eulàlia Sans-Serramitjana, Javiera F Santander, Mariela R Sánchez, Paulina Salazar-Aguilar, Andrea B Zepeda, Susana I Alvarado, Ignacia B Miranda

Open access · diamondAbstract readReview
In one paragraph

Review in Journal of clinical and experimental dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Review
  3. Oral Gel Formulation ofPharmaceutics · 2025
    Article
  4. A Topical Combination of Xyloglucan and Pea Protein Effectively Manages Oral Ulcers In Vivo.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2025
    Article
  5. Article
  6. Article
  7. Hyaluronic acid-based gels for oral application: Comparison ofJournal of oral biology and craniofacial research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Schilin D WenGrupo de investigación en Ciencias Aplicadas a la Odontología, Facultad Ciencias de la Salud, Universidad Autónoma de Chile, Chile.
Eulàlia Sans-SerramitjanaGrupo de investigación en Ciencias Aplicadas a la Odontología, Facultad Ciencias de la Salud, Universidad Autónoma de Chile, Chile.
Javiera F SantanderGrupo de investigación en Ciencias Aplicadas a la Odontología, Facultad Ciencias de la Salud, Universidad Autónoma de Chile, Chile.
Mariela R SánchezGrupo de investigación en Ciencias Aplicadas a la Odontología, Facultad Ciencias de la Salud, Universidad Autónoma de Chile, Chile.
Paulina Salazar-AguilarGrupo de investigación en Ciencias Aplicadas a la Odontología, Facultad Ciencias de la Salud, Universidad Autónoma de Chile, Chile.
Andrea B ZepedaGrupo de investigación en Ciencias Aplicadas a la Odontología, Facultad Ciencias de la Salud, Universidad Autónoma de Chile, Chile.
Susana I AlvaradoGrupo de investigación en Ciencias Aplicadas a la Odontología, Facultad Ciencias de la Salud, Universidad Autónoma de Chile, Chile.
Ignacia B MirandaGrupo de investigación en Ciencias Aplicadas a la Odontología, Facultad Ciencias de la Salud, Universidad Autónoma de Chile, Chile.
Universidad Autónoma de Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the clinical and histopathological effects of natural extracts in the treatment of oral ulcers induced in animal experimental models. MATERIAL AND

methodsWe carried out a search in the Medline, Scopus, WoS and Embase databases from the start of the databases to December 2020, and also made a manual search of the references. The search and selection were carried out by two researchers independently. The inclusion criteria were: experimental studies in animal models, in english, which complied with the study object.

resultsA total of 705 articles were identified. After selection by title, abstract and full text, 19 articles were finally included. Natural extracts of

conclusionsMost of the natural extracts described in this review presented a positive clinical and histological effect on the cicatrisation of oral ulcers induced in animal models.

Identifiers

PMID34667500
PMCPMC8501866
OpenAlexW3204103823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.