Evidence map›Paper›PMID 34667437›Full record

ArticleContemporary oncology (Poznan, Poland)2021

Forkhead box M1 over-expression and dachshund homolog 1 down-regulation as novel biomarkers for progression of endometrial carcinoma in Egyptian patients.

Abeer M Hafez, Ola A Harb, Waleed M Etman, Basem Hamed, Alfred E Namour, Lobna A Abdelaziz

Open access · goldAbstract read
In one paragraph

Article in Contemporary oncology (Poznan, Poland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Abeer M HafezDepartment of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ola A HarbDepartment of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Waleed M EtmanDepartment of Gynecology and Obstetrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Basem HamedDepartment of Gynecology and Obstetrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Alfred E NamourMedical Oncology Department, National Cancer Institute, Egypt.
Lobna A AbdelazizClinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Zagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionForkhead box M1 (FOXM1) is considered as a novel anti-cancer target, because it has many essential functions such as mitosis regulation, cell cycle transition, and other carcinogenesis signaling pathways. Dachshund homolog 1 (DACH1) is a member of the Sno/Ski co-repressor family. MATERIAL AND

methodsExpression of DACH1 has been detected in many cancers. Patients and pathologic specimens: 50 patients with endometrial cancer (EC) were included in the study: ten specimens of normal endometrium and twenty specimens of endometrial hyperplasia. All samples underwent processing to investigate FOXM1 and DACH1 expression using immunohistochemistry.

resultsFOXM1 expression was detected in EC tissues more than normal endometrium and endometrial hyperplasia tissues (

conclusionsFOXM1 over-expression and DACH1 down-regulation in EC were related to poor clinical and pathological parameters and unfavorable prognosis.

Indexed as

endometrial cancerFOXM1 and DACH1immunohistochemistryprognosis

Identifiers

PMID34667437
PMCPMC8506436
OpenAlexW3184900303

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.