ArticleScientific reports2021
Heritability and genetic correlations of plasma metabolites of pigs with production, resilience and carcass traits under natural polymicrobial disease challenge.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Prediction of disease resilience of pigs using multi-omics data.Journal of animal science and biotechnology · 2026Article
- Haematopoietic Traits in Indigenous and Modern Pig Breeds Are Modulated by Housing System and Developmental Stage.Animal genetics · 2026Article
- Uncovering the Genetic Basis of Porcine Resilience Through GWAS of Feed Intake Data.Animals : an open access journal from MDPI · 2025Article
- Alginate oligosaccharide supplementation improves boar semen quality under heat stress.Stress biology · 2024Article
- Serum metabolic profile and metabolome genome-wide association study in chicken.Journal of animal science and biotechnology · 2023Article
- Insight into the long-term impact of birth weight on intestinal development, microbial settlement, and the metabolism of weaned piglets.Journal of animal science · 2023Article
- Exploration of plasma metabolite levels in healthy nursery pigs in response to environmental enrichment and disease resilience.Journal of animal science · 2023Article
- GWAS and genetic and phenotypic correlations of plasma metabolites with complete blood count traits in healthy young pigs reveal implications for pig immune response.Frontiers in molecular biosciences · 2023Article
- Breeding for disease resilience: opportunities to manage polymicrobial challenge and improve commercial performance in the pig industry.CABI agriculture and bioscience · 2022Review
- Relationship between indirect genetic effects for growth, environmental enrichment, coping style and sex with the serum metabolome profile of pigs.Scientific reports · 2021Article
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9 authors.
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Abstract
Metabolites in plasma of healthy nursery pigs were quantified using nuclear magnetic resonance. Heritabilities of metabolite concentration were estimated along with their phenotypic and genetic correlations with performance, resilience, and carcass traits in growing pigs exposed to a natural polymicrobial disease challenge. Variance components were estimated by GBLUP. Heritability estimates were low to moderate (0.11 ± 0.08 to 0.19 ± 0.08) for 14 metabolites, moderate to high (0.22 ± 0.09 to 0.39 ± 0.08) for 17 metabolites, and highest for L-glutamic acid (0.41 ± 0.09) and hypoxanthine (0.42 ± 0.08). Phenotypic correlation estimates of plasma metabolites with performance and carcass traits were generally very low. Significant genetic correlation estimates with performance and carcass traits were found for several measures of growth and feed intake. Interestingly the plasma concentration of oxoglutarate was genetically negatively correlated with treatments received across the challenge nursery and finisher (- 0.49 ± 0.28; P < 0.05) and creatinine was positively correlated with mortality in the challenge nursery (0.85 ± 0.76; P < 0.05). These results suggest that some plasma metabolite phenotypes collected from healthy nursery pigs are moderately heritable and genetic correlations with measures of performance and resilience after disease challenge suggest they may be potential genetic indicators of disease resilience.
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