Evidence map›Paper›PMID 34667246›Full record

ArticleScientific reports2021

Economical droplet-based microfluidic production of [

Ksenia Lisova, Jia Wang, Tibor Jacob Hajagos, Yingqing Lu, Alexander Hsiao, Arkadij Elizarov, R Michael van Dam

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. High-efficiency [EJNMMI radiopharmacy and chemistry · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. The Imageable Genome.Nature communications · 2023
    Article
  8. Article
  9. Article
  10. Detrimental impact of aqueous mobile phases on 18F-labelled radiopharmaceutical analysisAnalytical methods : advancing methods and applications · 2023
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ksenia Lisova *Crump Institute for Molecular Imaging, University of California Los Angeles, Los Angeles, CA, USA.
Jia Wang *Crump Institute for Molecular Imaging, University of California Los Angeles, Los Angeles, CA, USA.
Tibor Jacob HajagosTrace-Ability, Inc., Van Nuys, CA, USA.
Yingqing LuCrump Institute for Molecular Imaging, University of California Los Angeles, Los Angeles, CA, USA.
Alexander HsiaoSOFIE, Inc., Dulles, VA, USA.
Arkadij ElizarovTrace-Ability, Inc., Van Nuys, CA, USA.
R Michael van DamCrump Institute for Molecular Imaging, University of California Los Angeles, Los Angeles, CA, USA. mvandam@mednet.ucla.edu.

Funding

Research Training in Biomedical PhysicsT32EB002101 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Michael F McNitt-Gray · 2003 to 2026
$5.3M
Commercialization of a Benchtop Radiosynthesizer for the Production of PET ProbesR44MH097271 · NIMH · SOFIE BIOSCIENCES, INC. · PI MOORE, MELISSA · 2013 to 2018
$3.8M
Optimization and validation of integrated microscale technologies for low-cost, automated production of PET molecular imaging tracers for cancer researchR33CA240201 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VAN DAM, ROBERT MICHAEL · 2019 to 2021
$1.1M
High-throughput radiochemistry platform for accelerated discovery and development of novel PET imaging agents for cancerR21CA212718 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VAN DAM, ROBERT MICHAEL · 2017 to 2018
$616k
NCI NIH HHS R21 CA212718NCI NIH HHS R33 CA240201NIBIB NIH HHS T32 EB002101NIMH NIH HHS R44 MH097271
6 · The paper itself

Abstract

Current equipment and methods for preparation of radiopharmaceuticals for positron emission tomography (PET) are expensive and best suited for large-scale multi-doses batches. Microfluidic radiosynthesizers have been shown to provide an economic approach to synthesize these compounds in smaller quantities, but can also be scaled to clinically-relevant levels. Batch microfluidic approaches, in particular, offer significant reduction in system size and reagent consumption. Here we show a simple and rapid technique to concentrate the radioisotope, prior to synthesis in a droplet-based radiosynthesizer, enabling production of clinically-relevant batches of [

Indexed as

Chromatography, High Pressure LiquidFluoridesFluorine RadioisotopesHumansMicrofluidicsPositron-Emission TomographyRadiochemistryRadioisotopesRadiopharmaceuticalsTomography, X-Ray ComputedFluoridesFluorine RadioisotopesRadioisotopesRadiopharmaceuticals

Identifiers

PMID34667246
PMCPMC8526601

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.