Evidence map›Paper›PMID 34667111›Full record

ArticleMolecular cancer therapeutics2022

Intraperitoneal Pretargeted Radioimmunotherapy for Colorectal Peritoneal Carcinomatosis.

Christopher S Chandler, Meghan M Bell, Sebastian K Chung, Darren R Veach, Edward K Fung, Blesida Punzalan, Daniela Burnes Vargas, Mitesh Patel, Hong Xu, Hong-Fen Guo and 10 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Nuclear Imaging of Bispecific Antibodies on the Rise.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Review
  6. Theranostic GPA33-Pretargeted Radioimmunotherapy of Human Colorectal Carcinoma with a BivalentJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  7. Article
  8. Review
  9. Review
  10. Efficacy of HER2-Targeted IntraperitonealJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  11. Role of Computed Tomography in the Evaluation of Peritoneal Carcinomatosis.Journal of the Belgian Society of Radiology · 2023
    Review
  12. Antibody Engineering for Nuclear Imaging and Radioimmunotherapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Christopher S ChandlerDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Meghan M BellDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Sebastian K ChungDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-5165-4360
Darren R VeachDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-8201-622X
Edward K FungDepartment of Radiology, Weill Cornell Medicine, New York, New York.
Blesida PunzalanDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Daniela Burnes VargasDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Mitesh PatelDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Hong XuDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
Hong-Fen GuoDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-5111-6009
Brian H SantichDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-5869-3661
Pat B ZanzonicoDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Sébastien MonetteLaboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, New York.ORCID 0000-0003-2841-6887
Garrett M NashDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Andrea CercekDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Achim JungbluthDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Neeta Pandit-TaskarDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0003-1551-2036
Nai Kong V CheungDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-6323-5171
Steven M LarsonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-6111-7507
Sarah M ChealMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York. cheals@mskcc.org.ORCID 0000-0003-1720-8994
Memorial Sloan Kettering Cancer Center · USCornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Tumor Evolution and Changes in MetabolismP50CA086438 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI LARSON, STEVEN MARK · 2000 to 2015
$29.9M
Weill Cornell Medicine (WCM) SPORE in Prostate CancerP50CA211024 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LODA, MASSIMO · 2017 to 2021
$10.9M
DOTA-based pre-targeting of alpha emittersR01CA233896 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEAL, SARAH MARIE · 2019 to 2023
$3.4M
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA086438NCI NIH HHS P50 CA211024NCI NIH HHS R01 CA233896
6 · The paper itself

Abstract

Peritoneal carcinomatosis (PC) is considered incurable, and more effective therapies are needed. Herein we test the hypothesis that GPA33-directed intracompartmental pretargeted radioimmunotherapy (PRIT) can cure colorectal peritoneal carcinomatosis. Nude mice were implanted intraperitoneally with luciferase-transduced GPA33-expressing SW1222 cells for aggressive peritoneal carcinomatosis (e.g., resected tumor mass 0.369 ± 0.246 g;

Indexed as

AnimalsColorectal NeoplasmsDisease Models, AnimalHumansMiceMice, NudePeritoneal NeoplasmsRadioimmunotherapy

Identifiers

PMID34667111
PMCPMC9157533
OpenAlexW3205382097

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.