Evidence map›Paper›PMID 34666940›Full record

ReviewTrends in endocrinology and metabolism: TEM2021

Caudamins, a new subclass of protein hormones.

Bijoya Basu, Mahim Jain, Atul R Chopra

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bijoya BasuHarrington Discovery Institute, University Hospitals, Cleveland, OH, USA; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Mahim JainKennedy Krieger Institute, Baltimore, MD, USA.
Atul R ChopraHarrington Discovery Institute, University Hospitals, Cleveland, OH, USA; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA; Department of Medicine, Case Western Reserve University, Cleveland, OH, USA. Electronic address: atul.chopra@case.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Asprosin, body weight, and risk of type 2 diabetes in U.S. men and womenR01DK125403 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHOPRA, ATUL, LIU, SIMIN · 2020 to 2022
$2.1M
ASPROSIN NEUTRALIZATION AS A NOVEL ANTI-OBESITY TREATMENTR01DK118290 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI CHOPRA, ATUL · 2018 to 2022
$2.0M
NIDDK NIH HHS R01 DK118290NIDDK NIH HHS R01 DK125403NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

Hormones have traditionally been classified by their mode of biosynthetic origin. We postulate a mode of hormone biosynthesis that leads to a new subclass of protein hormones. Members of this class are derived from a cleavage event that also generates a much larger, functionally unrelated, nonhormonal protein. Here, we examine four representative members of this group: endostatin, endotrophin, asprosin, and placensin. We have named this subclass of protein hormones caudamins, from the Latin word cauda meaning 'tail'. These four caudamins have shown promise in understanding and treating diseases like metabolic syndrome and cancer. Identification of the rest of the caudamins will likely provide a plethora of drug targets for a variety of diseases.

Indexed as

HormonesHumansHormones

Identifiers

PMID34666940
PMCPMC8585694

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.