Evidence map›Paper›PMID 34666738›Full record

ArticleBMC pediatrics2021

Prenatal prognostic factors for isolated right congenital diaphragmatic hernia: a single center's experience.

Jiyoon Jeong, Byong Sop Lee, Teahyen Cha, Euiseok Jung, Ellen Ai-Rhan Kim, Ki-Soo Kim, Dae Yeon Kim, Jung-Man Namgoong, Seong Chul Kim, Mi-Young Lee and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Feasibility of invasive neurally-adjusted ventilatory assist in severe congenital diaphragmatic hernia.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Observational
  3. Article
  4. Article
  5. Review
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jiyoon JeongDepartment of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center Children's Hospital, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Byong Sop LeeDepartment of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center Children's Hospital, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea. mdleebs@amc.seoul.kr.
Teahyen ChaDepartment of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center Children's Hospital, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Euiseok JungDepartment of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center Children's Hospital, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Ellen Ai-Rhan KimDepartment of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center Children's Hospital, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Ki-Soo KimDepartment of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center Children's Hospital, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Dae Yeon KimDepartment of Pediatric Surgery, University of Ulsan College of Medicine, Asan Medical Center Children's Hospital, Seoul, Korea.
Jung-Man NamgoongDepartment of Pediatric Surgery, University of Ulsan College of Medicine, Asan Medical Center Children's Hospital, Seoul, Korea.
Seong Chul KimDepartment of Pediatric Surgery, University of Ulsan College of Medicine, Asan Medical Center Children's Hospital, Seoul, Korea.
Mi-Young LeeDepartment of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Hye-Sung WonDepartment of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea. hswon@amc.seoul.kr.
University of Ulsan · KRUlsan College · KRAsan Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRight-sided congenital diaphragmatic hernia (RCDH) is relatively rare compared with left-sided congenital diaphragmatic hernia (LCDH). Clinical data of RCDH, especially with respect to antenatal prediction of neonatal outcome, are lacking. The aim of this study was to report the treatment outcomes of patients with antenatally diagnosed RCDH and to evaluate the predictability of observed-to-expected lung area-to-head circumference ratio (O/E LHR) for perinatal outcomes, focused on mortality or extracorporeal membrane oxygenation (ECMO) requirement.

methodsWe retrospectively reviewed the medical records of newborn infants with isolated RCDH. We analyzed and compared the clinical and prenatal characteristics including the fetal lung volume, which was measured as the O/E LHR, between the survivors and the non-survivors.

resultsA total of 26 (66.7%) of 39 patients with isolated RCDH survived to discharge. The O/E LHR was significantly greater in survivors (64.7 ± 21.2) than in non-survivors (40.5 ± 23.4) (P =.027). It was greater in survivors without ECMO requirement (68.3 ± 15.1) than non-survivors or those with ECMO requirement (46.3 ± 19.4; P = .010). The best O/E LHR cut-off value for predicting mortality in isolated RCDH was 50.

conclusionsThe findings in this study suggest that O/E LHR, a well-characterized prognostic indicator in LCDH, could be applied to a fetus with antenatally diagnosed RCDH. A large cohort study is required to verify the association between O/E LHR values and the graded severity of RCDH.

Indexed as

Hernias, Diaphragmatic, CongenitalFemaleGestational AgeHumansInfantInfant, NewbornLungPregnancyPrognosisRetrospective StudiesUltrasonography, PrenatalCongenital diaphragmatic herniaExtracorporeal membrane oxygenationObserved-to-expected lung area-to-head circumference ratioRight-sided congenital diaphragmatic hernia

Identifiers

PMID34666738
PMCPMC8526355
OpenAlexW3192819262

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.