Evidence map›Paper›PMID 34666725›Full record

ArticleBMC pediatrics2021

Diagnostic value of monocyte chemoattractant Protein-1, soluble mannose receptor, Presepsin, and Procalcitonin in critically ill children admitted with suspected sepsis.

Noha A Hassuna, Ebtesam Elgezawy, Suzan O Mousa, Reem A AbdelAziz, Reham A Ibrahem, Wafaa Yousif Abdel Wahed, Khalid A Nasif, Enas M Hefzy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Noha A HassunaMedical Microbiology and Immunology Department, Faculty of Medicine, Minia University, Minia, Egypt.
Ebtesam ElgezawyClinical Pathology Department, Faculty of Medicine, Assiut University, Asyut, Egypt.
Suzan O MousaPediatrics Department, Faculty of Medicine, Minia University, Minia, 61111, Egypt.
Reem A AbdelAzizPediatrics Department, Faculty of Medicine, Minia University, Minia, 61111, Egypt. reemabdelsalam3@gmail.com.
Reham A IbrahemMicrobiology and Immunology, Faculty of Pharmacy, Minia University, Minia, Egypt.
Wafaa Yousif Abdel WahedPublic Health Department, Faculty of Medicine, Fayoum University, Faiyum, Egypt.
Khalid A NasifBiochemistry Department, Faculty of Medicine, Minia University, Minia, Egypt.
Enas M HefzyMedical Microbiology and Immunology Department Faculty of Medicine, Fayoum University, Faiyum, Egypt.
Minia University · EGFayoum University · EGAssiut University · EGKing Khalid University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe differentiation between systemic inflammatory response syndrome and sepsis is very important as it determines essential treatment decisions, such as selection, initiation, and duration of antibiotic therapy.

objectivesWe aimed to investigate the diagnostic value of Procalcitonin, Monocyte Chemoattractant Protein-1, soluble Mannose Receptor, Presepsin as early biomarkers of pediatric sepsis in comparison to systemic inflammatory response syndrome in severely ill children. PATIENTS AND

methodsThis study included 58 children diagnosed as sepsis (group 1), 24 children with systemic inflammatory response syndrome without infection (group 2), and 50 healthy children as controls (group 3). All the plasma levels of the studied biomarkers were measured and ROC curves were created for all the tested parameters to discriminate between sepsis and SIRS.

resultsThe area under the curve for Monocyte Chemoattractant Protein-1 was 0.926 (0.846-0.927) with sensitivity 100% and specificity 62.5%. The soluble Mannose Receptor had the highest sensitivity (100%), with AUC equals 1(.0.956-1.0) and specificity of 100%. The cut-off values for Procalcitonin, Presepsin, soluble Mannose Receptor, and Monocyte Chemoattractant Protein-1 and were: 0.62 ng/ml, 100 pg/ml, 13 ng/ml and 90 pg/ml, respectively. In septic cases, both soluble Mannose Receptor and Procalcitonin have positive correlations with the severity of sepsis, low Glasgow Coma Scale, ventilatory support, use of inotropic drugs and mortality rate (r = 0.950, 0.812, 0.795, 0.732 and 0.861respectively) for soluble Mannose Receptor and (0.536, 0.473, 0.422, 0.305 and 0.474 respectively) for Procalcitonin.

conclusionSoluble Mannose Receptor, Presepsin, and Monocyte Chemoattractant Protein-1 can be used to differentiate between sepsis and SIRS in critically ill children.

Indexed as

ProcalcitoninSepsisBiomarkersChemokine CCL2ChildC-Reactive ProteinCritical IllnessHumansLectins, C-TypeLipopolysaccharide ReceptorsMannose-Binding LectinsMannose ReceptorPeptide FragmentsReceptors, Cell SurfaceSystemic Inflammatory Response SyndromeBiomarkersChemokine CCL2C-Reactive ProteinLectins, C-TypeLipopolysaccharide ReceptorsMannose-Binding LectinsMannose ReceptorPeptide Fragmentspresepsin protein, humanProcalcitoninReceptors, Cell SurfacePresepsinProcalcitoninSepsisSIRSSoluble mannose receptor

Identifiers

PMID34666725
PMCPMC8524917
OpenAlexW3207701030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.