ArticleBMC cancer2021
HRCT features between lepidic-predominant type and other pathological subtypes in early-stage invasive pulmonary adenocarcinoma appearing as a ground-glass nodule.
Article in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 24 citations in OpenAlex.
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- The role of radiological imaging in differentiating malignant and benign pulmonary nodules: a retrospective study.BMC medical imaging · 2026Article
- Non-resolving Pulmonary Consolidation Mimicking Tuberculosis: A Diagnostic Pitfall Revealing Lung Adenocarcinoma.Cureus · 2026Article
- Is the consolidation-to-tumor ratio an independent prognostic factor in clinical T1 stage lung adenocarcinoma radiologically manifesting as a subsolid nodule?-a retrospective cohort study.Journal of thoracic disease · 2026Article
- Artificial intelligence-based density proportion analysis in predicting the invasiveness of neoplastic ground-glass nodules.Translational lung cancer research · 2026Article
- Bio-interpretable ensemble learning model for invasive pulmonary adenocarcinoma grade using CT and histopathology images.NPJ precision oncology · 2025Article
- Contrast-enhanced computed tomography-based intratumoral and peritumoral radiomics for identifying malignancy in pulmonary ground-glass nodules.Journal of thoracic disease · 2025Article
- Identification of the optimal threshold for predicting the infiltration degree of T1-stage lung adenocarcinoma using solid component volume and three-dimensional consolidation-to-tumor ratio in threshold segmentation.Quantitative imaging in medicine and surgery · 2025Article
- Three-dimensional and magnified CT images of displaying the imaging features of invasive adenocarcinoma of lung.World journal of surgical oncology · 2025Article
- Quantitative parameters of HRCT target scan to predict the risk of lung adenocarcinoma based on the detection of lung ground-glass nodules.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- The value of non-enhanced CT 3D visualization in differentiating stage Ⅰ invasive lung adenocarcinoma between LPA and non-LPA.European journal of radiology open · 2024Article
- The clinical, radiological, postoperative pathological, and genetic features of nodular lung adenocarcinoma: a real-world single-center data.Journal of thoracic disease · 2024Article
- The predictive value of computed tomography value on high-resolution images in differentiating invasive from indolent lung adenocarcinoma.Translational cancer research · 2024Article
- CT morphological features and histogram parameters to predict micropapillary or solid components in stage IA lung adenocarcinoma.Frontiers in oncology · 2024Article
- A Bi-LSTM and multihead attention-based model incorporating radiomics signatures and radiological features for differentiating the main subtypes of lung adenocarcinoma.Quantitative imaging in medicine and surgery · 2023Article
- Prediction of high-grade patterns of stage IA lung invasive adenocarcinoma based on high-resolution CT features: a bicentric study.European radiology · 2023Article
- [Establishment and Verification of Benign and Malignant Prediction Model of Subcentimeter Pulmonary Ground Glass Nodules Based on HRCT].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023Article
- Nomogram combining clinical and radiological characteristics for predicting the malignant probability of solitary pulmonary nodules measuring ≤ 2 cm.Frontiers in oncology · 2023Article
- Establishment and validation a prediction model for discrimination of invasive adenocarcinomas for patients with peripheral pulmonary subsolid nodules.Annals of translational medicine · 2022Article
- A retrospective diagnostic test study on circulating tumor cells and artificial intelligence imaging in patients with lung adenocarcinoma.Annals of translational medicine · 2022Article
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5 authors at 1 institution in 1 country.
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Abstract
backgroundDifferent pathological subtypes of invasive pulmonary adenocarcinoma (IPA) have different surgical methods and heterogeneous prognosis. It is essential to clarify IPA subtypes before operation and high-resolution computed tomography (HRCT) plays a very important role in this regard. We aimed to investigate the HRCT features of lepidic-predominant type and other pathological subtypes of early-stage (T1N0M0) IPA appearing as a ground-glass nodule (GGN).
methodsWe performed a retrospective analysis on clinical data and HRCT features of 630 lesions in 589 patients with pathologically confirmed IPA (invasive foci > 5 mm) appearing as pure GGN (pGGN) and mixed GGN (mGGN) with consolidation-to-tumor ratio (CTR) ≤0.5 from January to December 2019. All GGNs were classified as lepidic-predominant adenocarcinoma (LPA) and nonlepidic-predominant adenocarcinoma (n-LPA) groups. Univariate analysis was performed to analyze the differences of clinical data and HRCT features between the LPA and n-LPA groups. Multivariate analysis was conducted to determine the variables to distinguish the LPA from n-LPA group independently. The diagnostic performance of different parameters was compared using receiver operating characteristic curves.
resultsIn total, 367 GGNs in the LPA group and 263 GGNs in the n-LPA group were identified. In the univariate analysis, the CTR, mean CT values, and mean diameters as well as mixed GGN, deep lobulation, spiculation, vascular change, bronchial change, and tumor-lung interface were smaller in the LPA group than in the n-LPA group (P < 0.05). Logistic regression model was reconstructed including the mean CT value, CTR, deep lobulation, spiculation, vascular change, and bronchial change (P < 0.05). Area under the curve of the logistic regression model for differentiating LPA and n-LPA was 0.840 (76.4% sensitivity, 78.7% specificity), which was significantly higher than that of the mean CT value or CTR.
conclusionsDeep lobulation, spiculation, vascular change, and bronchial change, CT value > - 472.5 HU and CTR > 27.4% may indicate nonlepidic predominant invasive pulmonary adenocarcinoma in GGNs.
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