Evidence map›Paper›PMID 34666595›Full record

ArticleBioengineered2021

Cytochrome P450 2J2 inhibits the proliferation and angiogenesis of retinal vascular endothelial cells by regulating the Notch signaling pathway in a hypoxia-induced retinopathy model.

Jing Zhang, Qi Xiong, Lin Yang, Yanni Xue, Min Ke, Zhi Li

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jing ZhangDepartment of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Qi XiongDepartment of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Lin YangDepartment of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yanni XueDepartment of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Min KeDepartment of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Zhi LiDepartment of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Wuhan University · CNZhongnan Hospital of Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinopathy of Prematurity (ROP), a type of retinal neovascularization in premature infants, has become a serious problem that drastically affects the quality of life of premature infants. ROP is associated with angiogenesis and neovascularization. Here, we aimed to explain the function and latent roles of Cytochrome P450 2J2 (CYP2J2) in hypoxia-induced retinopathy in retinal vascular endothelial cells (HRVECs). HRVECs were stimulated with hypoxia for 24 h to establish an

Indexed as

ApoptosisCell ProliferationCells, CulturedCell SurvivalCytochrome P-450 Enzyme SystemDown-RegulationEndothelial CellsHumansHypoxiaNeovascularization, PathologicReceptors, NotchRetinaRetinal DiseasesSignal TransductionCytochrome P-450 Enzyme SystemReceptors, NotchCYP2J2hypoxia-induced retinopathyNotch pathwayretinal vascular endothelial cells

Identifiers

PMID34666595
PMCPMC8809993
OpenAlexW3205314754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.