Evidence map›Paper›PMID 34666517›Full record

ArticleProceedings. Biological sciences2021

Antibiotics accelerate growth at the expense of immunity.

Juan A Galarza, Liam Murphy, Johanna Mappes

Open access · hybridAbstract read
In one paragraph

Article in Proceedings. Biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. The role of innate immunity, antibiotics, and bacteriophages in the course of bacterial infections and their treatment.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Molecular response ofCurrent research in toxicology · 2025
    Article
  8. The biological functions ofFrontiers in veterinary science · 2025
    Review
  9. Marine life science & technology · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Antibiotics accelerate growth at the expense of immunity.Proceedings. Biological sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Juan A GalarzaDepartment of Biological and Environmental Sciences, University of Jyväskylä, Survontie, 9, P.C. 40500, Jyväskylä, Finland.ORCID 0000-0003-3938-1798
Liam MurphyDepartment of Biological and Environmental Sciences, University of Jyväskylä, Survontie, 9, P.C. 40500, Jyväskylä, Finland.
Johanna MappesDepartment of Biological and Environmental Sciences, University of Jyväskylä, Survontie, 9, P.C. 40500, Jyväskylä, Finland.
University of Jyväskylä · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotics have long been used in the raising of animals for agricultural, industrial or laboratory use. The use of subtherapeutic doses in diets of terrestrial and aquatic animals to promote growth is common and highly debated. Despite their vast application in animal husbandry, knowledge about the mechanisms behind growth promotion is minimal, particularly at the molecular level. Evidence from evolutionary research shows that immunocompetence is resource-limited, and hence expected to trade off with other resource-demanding processes, such as growth. Here, we ask if accelerated growth caused by antibiotics can be explained by genome-wide trade-offs between growth and costly immunocompetence. We explored this idea by injecting broad-spectrum antibiotics into wood tiger moth (

Indexed as

Life History TraitsMothsAnimalsAnti-Bacterial AgentsBiological EvolutionLarvaAnti-Bacterial Agentsantibioticsgrowth promotionimmunity trade-offmicrobiome

Identifiers

PMID34666517
PMCPMC8527196
OpenAlexW3206827685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.