Evidence map›Paper›PMID 34666487›Full record

ArticleJournal of chemical information and modeling2021

Drug Repurposing to Identify Nilotinib as a Potential SARS-CoV-2 Main Protease Inhibitor: Insights from a Computational and

Souvik Banerjee, Shalini Yadav, Sourav Banerjee, Sayo O Fakayode, Jyothi Parvathareddy, Walter Reichard, Surekha Surendranathan, Foyez Mahmud, Ryan Whatcott, Joshua Thammathong and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of chemical information and modeling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Discovery of PLACS omega · 2023
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Small molecules in the treatment of COVID-19.Signal transduction and targeted therapy · 2022
    Review
  15. Designing Dual Inhibitors of Autotaxin-LPAR GPCR Axis.Molecules (Basel, Switzerland) · 2022
    Review
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Souvik BanerjeeDepartment of Physical Sciences, University of Arkansas Fort Smith, 5210 Grand Avenue, Fort Smith, Arkansas 72904, United States.ORCID 0000-0002-7811-2577
Shalini YadavDepartment of Chemistry, Shiv Nadar University, Gautam Buddha Nagar, Uttar Pradesh 201314, India.
Sourav BanerjeeDepartment of Chemistry, School of Basic and Applied Sciences, Adamas University, Kolkata 700126, India.
Sayo O FakayodeDepartment of Physical Sciences, University of Arkansas Fort Smith, 5210 Grand Avenue, Fort Smith, Arkansas 72904, United States.
Jyothi ParvathareddyRegional Biocontainment Laboratory, University of Tennessee Health Science Center, 901 Monroe Avenue, Memphis, Tennessee 38163, United States.
Walter ReichardDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Surekha SurendranathanRegional Biocontainment Laboratory, University of Tennessee Health Science Center, 901 Monroe Avenue, Memphis, Tennessee 38163, United States.
Foyez MahmudDepartment of Bioengineering, Rice University, 6100 Main Street, Houston, Texas 77005, United States.
Ryan WhatcottDepartment of Physical Sciences, University of Arkansas Fort Smith, 5210 Grand Avenue, Fort Smith, Arkansas 72904, United States.
Joshua ThammathongDepartment of Physical Sciences, University of Arkansas Fort Smith, 5210 Grand Avenue, Fort Smith, Arkansas 72904, United States.
Bernd MeibohmDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.ORCID 0000-0003-3923-3648
Duane D MillerDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.ORCID 0000-0002-6093-0985
Colleen B JonssonRegional Biocontainment Laboratory, University of Tennessee Health Science Center, 901 Monroe Avenue, Memphis, Tennessee 38163, United States.ORCID 0000-0002-2640-7672
Kshatresh Dutta DubeyDepartment of Chemistry, Shiv Nadar University, Gautam Buddha Nagar, Uttar Pradesh 201314, India.ORCID 0000-0001-8865-7602
University of Arkansas – Fort Smith · USUniversity of Tennessee Health Science Center · USShiv Nadar University · IN

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9M
NIGMS NIH HHS P20 GM103429
6 · The paper itself

Abstract

COVID-19, an acute viral pneumonia, has emerged as a devastating pandemic. Drug repurposing allows researchers to find different indications of FDA-approved or investigational drugs. In this current study, a sequence of pharmacophore and molecular modeling-based screening against COVID-19 M

Indexed as

COVID-19Protease InhibitorsAntiviral AgentsCoronavirus 3C ProteasesDrug RepositioningHumansMolecular Docking SimulationMolecular Dynamics SimulationPyrimidinesSARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesnilotinibProtease InhibitorsPyrimidines

Identifiers

PMID34666487
PMCPMC12126180
OpenAlexW3205285222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.