ArticlePsychiatry investigation2021
Alterations in the Occipital Cortex of Drug-Naïve Adults With Major Depressive Disorder: A Surface-Based Analysis of Surface Area and Cortical Thickness.
Article in Psychiatry investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Over-integration of visual network in major depressive disorder and its association with gene expression profiles.Translational psychiatry · 2025Article
- Increased individual variability in functional connectivity of the default mode network and its genetic correlates in major depressive disorder.Scientific reports · 2025Article
- Reduced cerebral cortex thickness is related to overexpression of exosomal miR-146a-5p in medication-free patients with major depressive disorder.Psychological medicine · 2023Article
- Shared and differential fractional amplitude of low-frequency fluctuation patterns at rest in major depressive disorders with or without sleep disturbance.Frontiers in psychology · 2023Article
- Sex differences of brain cortical structure in major depressive disorder.Psychoradiology · 2023Article
- Intrinsic Organization of Occipital Hubs Predicts Depression: A Resting-State fNIRS Study.Brain sciences · 2022Article
- Personalized Diagnosis and Treatment for Neuroimaging in Depressive Disorders.Journal of personalized medicine · 2022Review
- Neural activity changes in first-episode, drug-naïve patients with major depressive disorder after transcutaneous auricular vagus nerve stimulation treatment: A resting-state fMRI study.Frontiers in neuroscience · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
objectiveAdvances in surface-based morphometric methods have allowed researchers to separate cortical volume into cortical thickness (CTh) and surface area (SA). Although CTh alterations in major depressive disorder (MDD) have been observed in numerous studies, few studies have described significant SA alterations. Our study aimed to measure patients' SAs and to compare it with their CTh to examine whether SA exhibits alteration patterns that differ from those of CTh in drug-naïve patients with MDD.
methodsA total of 71 drug-naïve MDD patients and 111 healthy controls underwent structural magnetic resonance imaging, and SA and CTh were analyzed between the groups.
resultsWe found a smaller SA in the left superior occipital gyrus (L-SOG) in drug-naïve patients with MDD. In the CTh analysis, the bilateral fusiform gyrus, left middle occipital gyrus, left temporal superior gyrus, and right posterior cingulate showed thinner cortices in patients with MDD, while the CTh of the bilateral SOG, right straight gyrus, right posterior cingulate, and left lingual gyrus were increased.
conclusionCompared with the bilateral occipito-temporal changes in CTh, SA alterations in patients with MDD were confined to the L-SOG. These findings may improve our understanding of the neurobiological mechanisms of SA alteration in relation to MDD.
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