Trial reportJournal of cachexia, sarcopenia and muscle2021
A randomized clinical trial on the effects of exercise on muscle remodelling following bariatric surgery.
Trial report in Journal of cachexia, sarcopenia and muscle, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Enhancing Sarcopenia-Related Outcomes After Bariatric Surgery: A Systematic Review and Meta-Analysis of Exercise Interventions.Obesity surgery · 2026Pooled it
- Expert-based physical activity guidelines for metabolic and bariatric surgery patients: a systematic review of randomized controlled trials.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025Pooled it
- Pooled it
- Exploring the Acceptability of Post-bariatric Nutritional-Behavioral and Supervised Exercise Intervention (BARI-LIFESTYLE): A Mixed Methods Evaluation.Obesity surgery · 2025Trial
- Impact of a Multicomponent Exercise Training Program on Muscle Strength After Bariatric Surgery: A Randomized Controlled Trial.Obesity surgery · 2024Trial
- Exercise modifies hypothalamic connectivity and brain functional networks in women after bariatric surgery: a randomized clinical trial.International journal of obesity (2005) · 2023Trial
- A randomized clinical trial on the effects of exercise on muscle remodelling following bariatric surgery.Journal of cachexia, sarcopenia and muscle · 2021Trial
- Skeletal muscle reprogramming of metabolic, ribosomal and developmental pathways contributes to Roux-en-Y gastric bypass-induced adaptation in women.EBioMedicine · 2026Article
- Exercise reprograms the gut microbiota to enhance metabolic outcomes after bariatric surgery: a translational, cross-species study.International journal of obesity (2005) · 2026Article
- Is semaglutide a better weight-management option than bariatric surgery for patients undergoing total knee arthroplasty?Archives of orthopaedic and trauma surgery · 2026Article
- Multimodal Evaluation of Body Composition and Muscle Strength in Women Before and After Bariatric Surgery: A Clinical Observational Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Effects of exercise regimens on balance ability in older patients with osteoporosis: a systematic review and Bayesian network meta-analysis of randomized controlled trials.Frontiers in physiology · 2026Review
- Are we giving too much weight to lean mass loss?Molecular metabolism · 2025Review
- Sheer drop ahead: reviewing sarcopenia outcomes in elderly patients undergoing bariatric surgery.Reviews in endocrine & metabolic disorders · 2025Review
- Optimizing cardiorespiratory fitness after bariatric surgery - highly effective with very low adherence: HIT BAR randomized controlled trial.BMC sports science, medicine & rehabilitation · 2025Article
- Characteristics of changes in bone mineral density and body composition in obesity patients after metabolic and bariatric surgery: A prospective cohort study.Diabetes, obesity & metabolism · 2025Article
- Leisure-Time Physical Activity Patterns and Predictors in Patients Before and After Metabolic and Bariatric Surgery: A Cross-sectional Study.Obesity surgery · 2025Article
- Impact of Bariatric and Metabolic Surgery on Sarcopenia-Related Parameters According to the EWGSOP2 Consensus Criteria in Persons Living with Obesity.Obesity surgery · 2025Review
- Unraveling the multifaceted benefits of physical exercise: a comprehensive review of body composition, metabolic regulation, and systemic health.Frontiers in nutrition · 2025Review
- The Etiology of Reduced Muscle Mass with Surgical and Pharmacological Weight Loss and the Identification of Potential Countermeasures.Nutrients · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundMuscle atrophy and strength loss are common adverse outcomes following bariatric surgery. This randomized, controlled trial investigated the effects of exercise training on bariatric surgery-induced loss of muscle mass and function. Additionally, we investigated the effects of the intervention on molecular and histological mediators of muscle remodelling.
methodsEighty women with obesity were randomly assigned to a Roux-en-Y gastric bypass (RYGB: n = 40, age = 42 ± 8 years) or RYGB plus exercise training group (RYGB + ET: n = 40, age = 38 ± 7 years). Clinical and laboratory parameters were assessed at baseline, and 3 (POST3) and 9 months (POST9) after surgery. The 6 month, three-times-a-week, exercise intervention (resistance plus aerobic exercise) was initiated 3 months post-surgery (for RYGB + ET). A healthy, lean, age-matched control group was recruited to provide reference values for selected variables.
resultsSurgery resulted in a similar (P = 0.66) reduction in lower-limb muscle strength in RYGB and RYGB+ET (-26% vs. -31%), which was rescued to baseline values in RYGB + ET (P = 0.21 vs. baseline) but not in RYGB (P < 0.01 vs. baseline). Patients in RYGB+ET had greater absolute (214 vs. 120 kg, P < 0.01) and relative (2.4 vs. 1.4 kg/body mass, P < 0.01) muscle strength compared with RYGB alone at POST9. Exercise resulted in better performance in timed-up-and-go (6.3 vs. 7.1 s, P = 0.05) and timed-stand-test (18 vs. 14 repetitions, P < 0.01) compared with RYGB. Fat-free mass was lower (POST9-PRE) after RYBG than RYGB + ET (total: -7.9 vs. -4.9 kg, P < 0.01; lower-limb: -3.8 vs. -2.7 kg, P = 0.02). Surgery reduced Types I (~ - 21%; P = 0.99 between-group comparison) and II fibre cross-sectional areas (~ - 27%; P = 0.88 between-group comparison), which were rescued to baseline values in RYGB+ET (P > 0.05 vs. baseline) but not RYGB (P > 0.01 vs. baseline). RYGB + ET showed greater Type I (5187 vs. 3898 μm
conclusionsThis study provides compelling evidence-from gene to function-that strongly supports the incorporation of exercise into the recovery algorithm for bariatric patients so as to counteract the post-surgical loss of muscle mass and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.