ArticleCell systems2022
Multiomic profiling of the liver across diets and age in a diverse mouse population.
Article in Cell systems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 50 citations in OpenAlex.
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- Integrative analysis of the mouse cecal microbiome across diet, age, and weight in the diverse BXD population.Microbiome · 2026Article
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- Protein-level batch-effect correction enhances robustness in MS-based proteomics.Nature communications · 2025Article
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- The DREAM complex links somatic mutation, lifespan, and disease.bioRxiv : the preprint server for biology · 2025Article
- Analysis of lifespan across diversity outbred mouse studies identifies multiple longevity-associated loci.Genetics · 2025Article
- Proteomic and phosphoproteomic signatures of aging mouse liver.GeroScience · 2025Article
- Genetic modulation of protein expression in rat brain.iScience · 2025Article
- xOmicsShiny: an R Shiny application for cross-omics data analysis and pathway mapping.Bioinformatics advances · 2025Article
- The lifespan-extending MEK1 inhibitor trametinib promotes regulation of de novo lipogenesis enzymes by chaperone-mediated autophagy.Frontiers in aging · 2025Article
- AI-empowered perturbation proteomics for complex biological systems.Cell genomics · 2024Article
- An atlas of the aging mouse proteome reveals the features of age-related post-transcriptional dysregulation.Nature communications · 2024Article
- BERNN: Enhancing classification of Liquid Chromatography Mass Spectrometry data with batch effect removal neural networks.Nature communications · 2024Article
- Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans.Nature communications · 2024Article
- Chaperone-mediated autophagy as a modulator of aging and longevity.Frontiers in aging · 2024Review
- How is Big Data reshaping preclinical aging research?Lab animal · 2023Review
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Authors and funding
15 authors at 4 institutions in 4 countries.
Funding
Abstract
We profiled the liver transcriptome, proteome, and metabolome in 347 individuals from 58 isogenic strains of the BXD mouse population across age (7 to 24 months) and diet (low or high fat) to link molecular variations to metabolic traits. Several hundred genes are affected by diet and/or age at the transcript and protein levels. Orthologs of two aging-associated genes, St7 and Ctsd, were knocked down in C. elegans, reducing longevity in wild-type and mutant long-lived strains. The multiomics data were analyzed as segregating gene networks according to each independent variable, providing causal insight into dietary and aging effects. Candidates were cross-examined in an independent diversity outbred mouse liver dataset segregating for similar diets, with ∼80%-90% of diet-related candidate genes found in common across datasets. Together, we have developed a large multiomics resource for multivariate analysis of complex traits and demonstrate a methodology for moving from observational associations to causal connections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.