ArticleCurrent biology : CB2021
An electrically coupled pioneer circuit enables motor development via proprioceptive feedback in Drosophila embryos.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 49 citations in OpenAlex.
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- Characterizing stage-dependent neuromotor patterns inFrontiers in neuroscience · 2025Article
- CRASH2p: Closed-loop Two Photon Imaging in a Freely Moving Animal.bioRxiv : the preprint server for biology · 2024Article
- STEERING FROM THE REAR: COORDINATION OF CENTRAL PATTERN GENERATORS UNDERLYING NAVIGATION BY ASCENDING INTERNEURONS.bioRxiv : the preprint server for biology · 2024Article
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- Developmentally Unique Cerebellar Processing Prioritizes Self- over Other-Generated Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Developmentally unique cerebellar processing prioritizes self-over other-generated movements.bioRxiv : the preprint server for biology · 2024Article
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- Sleep, plasticity, and sensory neurodevelopment.Neuron · 2022Review
- Critical periods inFrontiers in physiology · 2022Review
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Precocious movements are widely seen in embryos of various animal species. Whether such movements via proprioceptive feedback play instructive roles in motor development or are a mere reflection of activities in immature motor circuits is a long-standing question. Here we image the emerging motor activities in Drosophila embryos that lack proprioceptive feedback and show that proprioceptive experience is essential for the development of locomotor central pattern generators (CPGs). Downstream of proprioceptive inputs, we identify a pioneer premotor circuit composed of two pairs of segmental interneurons, whose gap-junctional transmission requires proprioceptive experience and plays a crucial role in CPG formation. The circuit autonomously generates rhythmic plateau potentials via IP
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