ArticleMolecular ecology resources2022
DNA methylation as a tool to explore ageing in wild roe deer populations.
Article in Molecular ecology resources, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Independent Avian Epigenetic Clocks for Ageing and Development.Molecular ecology resources · 2025Article
- Estimating Polar Bear (Ecology and evolution · 2025Article
- Epigenetic Clock in Bears: A Simple Cost-Effective Blood DNA Methylation-Based Age Estimation Method Applicable to Multiple Bear Species.Ecology and evolution · 2025Article
- DNA Methylation Dynamics Reflect Sex and Status Differences in Mortality Rates in a Polygynous Bat.Molecular ecology · 2025Article
- Structural features of DNA and their potential contribution to blind mole rat (Nannospalax xanthodon) longevity.Biogerontology · 2025Article
- Noninvasive, epigenetic age estimation in an elasmobranch, the cownose ray (Rhinoptera bonasus).Scientific reports · 2024Article
- Pan-primate studies of age and sex.GeroScience · 2023Article
- Article
- DNA methylation networks underlying mammalian traits.Science (New York, N.Y.) · 2023Article
- Article
- Development of DNA methylation-based epigenetic age predictors in loblolly pine (Pinus taeda).Molecular ecology resources · 2023Article
- DNA methylation clocks for dogs and humans.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- DNA methylation as a tool to explore ageing in wild roe deer populations.Molecular ecology resources · 2022Article
- Article
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Authors and funding
13 authors.
Funding
Abstract
DNA methylation-based biomarkers of ageing (epigenetic clocks) promise to lead to new insights into evolutionary biology of ageing. Relatively little is known about how the natural environment affects epigenetic ageing effects in wild species. In this study, we took advantage of a unique long-term (>40 years) longitudinal monitoring of individual roe deer (Capreolus capreolus) living in two wild populations (Chizé and Trois-Fontaines, France) facing different ecological contexts, to investigate the relationship between chronological age and levels of DNA methylation (DNAm). We generated novel DNA methylation data from n = 94 blood samples, from which we extracted leucocyte DNA, using a custom methylation array (HorvathMammalMethylChip40). We present three DNA methylation-based estimators of age (DNAm or epigenetic age), which were trained in males, females, and both sexes combined. We investigated how sex differences influenced the relationship between DNAm age and chronological age using sex-specific epigenetic clocks. Our results highlight that old females may display a lower degree of biological ageing than males. Further, we identify the main sites of epigenetic alteration that have distinct ageing patterns between the two sexes. These findings open the door to promising avenues of research at the crossroads of evolutionary biology and biogerontology.
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