Evidence map›Paper›PMID 34665907›Full record

ArticleBipolar disorders2022

A graph theory-based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder.

Danielle A Goldman, Anjali Sankar, Lejla Colic, Luca Villa, Jihoon A Kim, Brian Pittman, R Todd Constable, Dustin Scheinost, Hilary P Blumberg

Open access · greenAbstract read
In one paragraph

Article in Bipolar disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Consensus Paper: Cerebellum and Reward.Cerebellum (London, England) · 2024
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 4 countries.

Danielle A GoldmanInterdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0003-1916-7372
Anjali SankarDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-7517-9776
Lejla ColicDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-8809-4034
Luca VillaDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-5091-6410
Jihoon A KimDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Brian PittmanDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
R Todd ConstableDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut, USA.
Dustin ScheinostDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut, USA.
Hilary P BlumbergDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-6363-4698
Yale University · USCopenhagen University Hospital · DK

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NRSA Training CoreTL1TR001864 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$9.9M
Genetics of Hippocampal Deficits in Bipolar DisorderR01MH070902 · NIMH · YALE UNIVERSITY · PI BLUMBERG, HILARY PATRICIA · 2005 to 2015
$5.1M
Development of Brain Abnormalities in Bipolar DisorderR01MH069747 · NIMH · YALE UNIVERSITY · PI BLUMBERG, HILARY PATRICIA · 2004 to 2008
$2.0M
Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that ConRC1MH088366 · NIMH · YALE UNIVERSITY · PI BLUMBERG, HILARY PATRICIA · 2009 to 2010
$998k
Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)UG3MH111929 · NIMH · YALE UNIVERSITY · PI BLUMBERG, HILARY PATRICIA · 2018 to 2019
$943k
Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)R61MH111929 · NIMH · YALE UNIVERSITY · PI BLUMBERG, HILARY PATRICIA · 2017 to 2017
$750k
NCATS NIH HHS TL1 TR001864NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH069747NIMH NIH HHS R01 MH070902NIMH NIH HHS R61 MH111929NIMH NIH HHS RC1 MH088366NIMH NIH HHS UG3 MH111929
6 · The paper itself

Abstract

objectivesIdentifying hubs of brain dysfunction in adolescents and young adults with Bipolar I Disorder (BD

methodsFunctional magnetic resonance imaging whole-brain ICD data were investigated for differences across four groups: BD

resultsICD was higher in the BD

conclusionsThis ICD approach supports a PFC hub of inter- and intra-hemispheric frontotemporal dysconnectivity in BD

Indexed as

Bipolar DisorderAdolescentBrainBrain MappingHumansMagnetic Resonance ImagingPrefrontal CortexYoung Adultadolescentbipolar disorderdepressionfMRIfunctional connectivitymood state

Identifiers

PMID34665907
PMCPMC9016085
OpenAlexW3206207819

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.