Evidence map›Paper›PMID 34665890›Full record

ArticlePsychophysiology2022

Acute effects of oral delta-9-tetrahydrocannabinol (THC) on autonomic cardiac activity and their relation to subjective and anxiogenic effects.

Elisa Pabon, Frederica Rockwood, Greg J Norman, Harriet de Wit

Open access · greenAbstract read
In one paragraph

Article in Psychophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Intoxication due to Δ9-tetrahydrocannabinol is characterized by disrupted prefrontal cortex activity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Heart rate response to cannabis in active older adults.European journal of applied physiology · 2026
    Article
  7. Article
  8. Parasympathetic decreases immediately following self-reported cannabis smoking among adults living with cannabis use disorder.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2025
    Article
  9. Understanding the Role of Endocannabinoids in Posttraumatic Stress Disorder.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Substance Use is Associated With College Students' Acute Parasympathetic Nervous System Responses to Challenge.Stress and health : journal of the International Society for the Investigation of Stress · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Elisa PabonDepartment of Psychiatry and Behavioral Neurosciences, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0001-6669-7259
Frederica RockwoodDepartment of Psychology, University of Chicago, Chicago, Illinois, USA.
Greg J NormanDepartment of Psychology, University of Chicago, Chicago, Illinois, USA.
Harriet de WitDepartment of Psychiatry and Behavioral Neurosciences, University of Chicago, Chicago, Illinois, USA.
University of Chicago · US

Funding

Determinants of Drug Preference in Humans--Administrative SupplementR01DA002812 · NIDA · UNIVERSITY OF CHICAGO · PI DE WIT, HARRIET · 1985 to 2024
$10.6M
University of Chicago Initiative for Maximizing Student Development (IMSD) - Renewal 01R25GM109439 · NIGMS · UNIVERSITY OF CHICAGO · PI SCHWARTZ, NANCY B · 2014 to 2023
$5.7M
Integrative Training in the Neurobiology of Addictive BehaviorsT32DA043469 · NIDA · UNIVERSITY OF CHICAGO · PI Donald Hedeker, Xiaoxi Zhuang · 2017 to 2026
$3.8M
Differential female response to delta-9-tetrahydrocannabinol (THC)F31DA049391 · NIDA · UNIVERSITY OF CHICAGO · PI PABON, ELISA · 2020 to 2021
$92k
NIDA NIH HHS F31 DA049391NIDA NIH HHS R01 DA002812NIDA NIH HHS T32 DA043469NIGMS NIH HHS R25 GM109439
6 · The paper itself

Abstract

Cannabis is the most commonly used psychotropic drug in the United States, after alcohol. Despite its apparent sedative and calming effects, cannabis and its main psychoactive constituent, ∆

Indexed as

Administration, OralAdultAnxietyBlood PressureCannabinoid Receptor AgonistsDronabinolFemaleHeart RateHumansParasympathetic Nervous SystemSympathetic Nervous SystemYoung AdultCannabinoid Receptor AgonistsDronabinolautonomicCannabisdelta-9-tetrahydrocannabinolheart rateheart rate variabilityimpedance cardiography

Identifiers

PMID34665890
PMCPMC8724445
OpenAlexW3206617498

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.