Evidence map›Paper›PMID 34665853›Full record

Trial reportSchizophrenia bulletin2022

Integrated Cognitive-Behavioral Social Skills Training and Compensatory Cognitive Training for Negative Symptoms of Psychosis: Effects in a Pilot Randomized Controlled Trial.

Eric Granholm, Elizabeth W Twamley, Zanjbeel Mahmood, Amber V Keller, Hannah C Lykins, Emma M Parrish, Michael L Thomas, Dimitri Perivoliotis, Jason L Holden

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02170051 (Improving Negative Symptoms of Psychosis In Real-world Environments), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02170051 nacompletednot on this map

Improving Negative Symptoms of Psychosis In Real-world Environments

TypeinterventionalSponsorUniversity of California, San DiegoRan2014 to 2018Enrolled64ConditionsSchizophreniaArmsCBSST-CCT, Goal focused supportive contact
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Eric GranholmDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Elizabeth W TwamleyDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-8693-8782
Zanjbeel MahmoodSDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Amber V KellerSDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Hannah C LykinsResearch Service and Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.
Emma M ParrishSDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Michael L ThomasPsychology Department, Colorado State University, Fort Collins, CO, USA.
Dimitri PerivoliotisDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Jason L HoldenDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
University of California San Diego · USSan Diego State University · USColorado State University · USVA San Diego Healthcare System · US

Funding

FELLOWSHIP IN GERIATRIC MENTAL HEALTHT32MH019934 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth W Twamley · 1994 to 2026
$9.5M
Improving Negative Symptoms of Psychosis In Real-World Environments - INSPIRER34MH101250 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANHOLM, ERIC L, TWAMLEY, ELIZABETH W · 2013 to 2015
$698k
NIMH NIH HHS R34 MH101250NIMH NIH HHS T32 MH019934
6 · The paper itself

Abstract

objectiveNegative symptoms and cognitive impairment in schizophrenia (SZ) remain unmet treatment needs as they are highly prevalent, associated with poor functional outcomes, and resistant to pharmacologic treatment. The current pilot randomized controlled trial examined the efficacy of an integrated Cognitive-Behavioral Social Skills Training and Compensatory Cognitive Training (CBSST-CCT) intervention compared to Goal-focused Supportive Contact (SC) on negative symptoms and cognitive performance.

methodsFifty-five adults with SZ or schizoaffective disorder with moderate-to-severe negative symptoms were randomized to receive 25 twice-weekly, 1-h manualized group sessions (12.5 weeks total duration) of either CBSST-CCT or SC delivered by master's level clinicians in five community settings. Assessments of negative symptom severity (primary outcomes) and neuropsychological performance, functional capacity, social skills performance, and self-reported functional ability/everyday functioning, psychiatric symptom severity, and motivation (secondary outcomes) were administered at baseline, mid-treatment, post-treatment, and 6-month follow-up.

resultsMixed-effects models using baseline, mid-treatment, and post-treatment data demonstrated significant CBSST-CCT-associated effects on negative symptom severity, as assessed by the Scale for the Assessment of Negative Symptoms (p = .049, r = 0.22), with improvements in diminished motivation driving this effect (p = .037, r = 0.24). The CBSST-CCT group also demonstrated improved verbal learning compared to SC participants (p = .026, r = 0.36). The effects of CBSST-CCT appeared to be durable at 6-month follow-up.

conclusionsCBSST-CCT improved negative symptom severity and verbal learning in high-negative-symptom individuals relative to SC. CBSST-CCT warrants larger investigations to examine its efficacy in treating negative symptoms, along with other symptoms, cognition, and, ultimately, real-world functional outcomes. Clinical Trial registration number NCT02170051.

Indexed as

AdultCognitive Behavioral TherapyFemaleHumansMaleMiddle AgedNeuropsychological TestsPilot ProjectsPsychotic DisordersSocial SkillsTreatment Outcomecognitive rehabilitationpsychosispsychosocial interventionsevere mental illness

Identifiers

PMID34665853
PMCPMC8886598
OpenAlexW3205674958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.