ArticlePloS one2021
Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cultural inclusivity and diversity in dementia friendly communities: An integrative review.Dementia (London, England) · 2023Pooled it
- Improving COVID-19 Vaccine Uptake among Black Populations: A Systematic Review of Strategies.International journal of environmental research and public health · 2022Pooled it
- Twenty-year trends in racial and ethnic enrollment in large diabetes randomized controlled trials.BMC medicine · 2022Pooled it
- Examining recruitment differences by race, ethnicity, and age to a decentralized trial of an internet-delivered intervention for sexual health after breast cancer: the WF-2202 SHINE trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Successful recruitment of monolingual Spanish speaking Latinos to university phase II and III outpatient COVID-19 clinical treatment trials in Northern California.Contemporary clinical trials · 2022Trial
- Trial
- Drivers of Research Participation Among Racially and Ethnically Underrepresented Women: Insights from Semi-Structured Interviews.Journal of racial and ethnic health disparities · 2026Article
- Strengthening Indigenous community engagement in clinical research: a formative evaluation in Northern British Columbia.BMJ global health · 2026Article
- Exploring meaning in culture: Insights from meaning-centered psychotherapy in Aotearoa, New Zealand.Palliative & supportive care · 2026Article
- Barriers and Opportunities to Include Underrepresented Population Groups in Vaccine Trials: Cross-Sectional, Observational, Online Survey Study From the VACCELERATE Research Network.JMIR public health and surveillance · 2026Observational
- Designing communication strategies to increase rural participation in clinical trials using the Health Belief Model and strategic communication.Contemporary clinical trials communications · 2026Article
- Guide on Selection of Optimal Motivational Themes for Use in a Clinical Trial Recruiting Black US Adults: Survey Study.Journal of medical Internet research · 2026Article
- A meta-review of patient engagement, shared decision-making, and factors influencing equity-deserving populations' participation in clinical trials.Research involvement and engagement · 2026Review
- Underrepresentation of Racial and Ethnic Minorities in Metastatic Colorectal Carcinoma Clinical Trials Within the United States.Annals of surgery · 2026Article
- Building Trust and Engaging Communities for HIV Prevention Research Globally.AIDS education and prevention : official publication of the International Society for AIDS Education · 2026Article
- Speaking Out: Factors Influencing Black Americans' Engagement in COVID-19 Testing and Research.Journal of racial and ethnic health disparities · 2026Article
- A pilot feasibility and acceptability evaluation of Trans Care: A CBPR digital health intervention for transgender and nonbinary adults experiencing gender dysphoria.International journal of transgender health · 2026Article
- The role of regional and practice trial sites in nonrepresentative randomized cancer trial enrollment.Journal of the National Cancer Institute · 2025Article
- Communicating the ethical, legal, and social issues in neurobiobanking and stroke genomic research in Africa: Project intervention tools development and evaluation procedures.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025Article
- Rapid development of a registry to accelerate COVID-19 vaccine clinical trials.NPJ digital medicine · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Longstanding social and economic inequities elevate health risks and vulnerabilities for Black, Indigenous and People of Color (BIPOC) communities. Engagement of BIPOC communities in infectious disease research is a critical component in efforts to increase vaccine confidence, acceptability, and uptake of future approved products. Recent data highlight the relative absence of BIPOC communities in vaccine clinical trials. Intentional and effective community engagement methods are needed to improve BIPOC inclusion. We describe the methods utilized for the successful enrollment of BIPOC participants in the U.S. Government (USG)-funded COVID-19 Prevention Network (CoVPN)-sponsored vaccine efficacy trials and analyze the demographic and enrollment data across the efficacy trials to inform future efforts to ensure inclusive participation. Across the four USG-funded COVID-19 vaccine clinical trials for which data are available, 47% of participants enrolled at CoVPN sites in the US were BIPOC. White enrollment outpaced enrollment of BIPOC participants throughout the accrual period, requiring the implementation of strategies to increase diverse and inclusive enrollment. Trials opening later benefitted considerably from strengthened community engagement efforts, and greater and more diverse volunteer registry records. Despite robust fiscal resources and a longstanding collaborative and collective effort, enrollment of White persons outpaced that of BIPOC communities. With appropriate resources, commitment and community engagement expertise, the equitable enrollment of BIPOC individuals can be achieved. To ensure this goal, intentional efforts are needed, including an emphasis on diversity of enrollment in clinical trials, establishment of enrollment goals, ongoing robust community engagement, conducting population-specific trials, and research to inform best practices.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.