Evidence map›Paper›PMID 34665521›Full record

ArticlePhysiological reports2021

Role of collecting duct principal cell NOS1β in sodium and potassium homeostasis.

Kelly A Hyndman, Elena Isaeva, Oleg Palygin, Luciano D Mendoza, Aylin R Rodan, Alexander Staruschenko, Jennifer S Pollock

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Kir5.1 channels: potential role in epilepsy and seizure disorders.American journal of physiology. Cell physiology · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Kelly A HyndmanDepartment of Medicine, Division of Nephrology, Section of Cardio-Renal Physiology and Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-8465-2588
Elena IsaevaDepartment of Cellular Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Oleg PalyginDivision of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Luciano D MendozaDepartment of Medicine, Division of Nephrology, Section of Cardio-Renal Physiology and Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Aylin R RodanMolecular Medicine Program, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0001-9202-2378
Alexander StaruschenkoDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida, USA.
Jennifer S PollockDepartment of Medicine, Division of Nephrology, Section of Cardio-Renal Physiology and Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
University of Alabama at Birmingham · USMedical College of Wisconsin · USMedical University of South Carolina · USUniversity of South Florida · USUniversity of Utah · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Research Supplement to Promote DiversityP01HL136267 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI POLLOCK, DAVID M · 2017 to 2021
$11.9M
Regulation of WNK signaling by potassium and Mo25: structure, function and physiologyR01DK110358 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RODAN, AYLIN RACHEL · 2016 to 2025
$4.1M
Renal ion channels in the control of blood pressureR35HL135749 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI STARUSCHENKO, ALEXANDER · 2017 to 2023
$3.6M
Role of basolateral K channels in renal salt handling and BP controlR01DK126720 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PALYGIN, OLEG · 2021 to 2024
$1.5M
Novel mechanisms of HDAC1 regulation of renal collecting duct functionK01DK105038 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HYNDMAN, KELLY · 2015 to 2019
$754k
Renal implications of AQP3 lysine acetylationR03DK120503 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HYNDMAN, KELLY · 2019 to 2020
$223k
Essential role of Kir4.1/Kir5.1 channels in renal salt handling and blood pressure controlR56DK121750 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI PALYGIN, OLEG · 2019 to 2019
$92k
Transport and metabolism in the kidneyI01BX004024 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI STARUSCHENKO, ALEXANDER · 2019 to 2025
–
BLRD VA I01 BX004024NHLBI NIH HHS P01 HL136267NHLBI NIH HHS R35 HL135749NIDDK NIH HHS K01 DK105038NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK110358NIDDK NIH HHS R01 DK126720NIDDK NIH HHS R03 DK120503NIDDK NIH HHS R56 DK121750
6 · The paper itself

Abstract

The nitric oxide (NO)-generating enzyme, NO synthase-1β (NOS1β), is essential for sodium (Na

Indexed as

HomeostasisAnimalsCHO CellsCricetinaeCricetulusIon TransportKcnj10 ChannelKidney Tubules, CollectingKir5.1 ChannelMaleMiceMice, KnockoutNitric Oxide Synthase Type IPotassiumPotassium Channels, Inwardly RectifyingSodiumKcnj10 ChannelKcnj16 protein, mouseKir5.1 ChannelNitric Oxide Synthase Type INos1 protein, mousePotassiumPotassium Channels, Inwardly RectifyingSodiumcollecting ducthigh saltKcnj10Kcnj16kidneyKir channelsnitric oxideNOS1βpotassium

Identifiers

PMID34665521
PMCPMC8525323
OpenAlexW3206498716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.