Evidence map›Paper›PMID 34665451›Full record

ReviewSports medicine (Auckland, N.Z.)2022

The Path Towards Progress: A Critical Review to Advance the Science of the Female and Male Athlete Triad and Relative Energy Deficiency in Sport.

Mary Jane De Souza, Nicole C A Strock, Emily A Ricker, Kristen J Koltun, Michelle Barrack, Elizabeth Joy, Aurelia Nattiv, Mark Hutchinson, Madhusmita Misra, Nancy I Williams

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Prevalence of physically active females at risk for the female athlete triad in Spain.Journal of the International Society of Sports Nutrition · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Editorial: Integrative exercise endocrinology.Frontiers in endocrinology · 2023
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Mary Jane De SouzaDepartment of Kinesiology and Physiology, Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0001-5185-9710
Nicole C A StrockDepartment of Kinesiology, Pennsylvania State University, University Park, PA, 16802, USA.
Emily A RickerConsortium for Health and Military Performance, Department of Military and Emergency Medicine, F. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, USA.
Kristen J KoltunDepartment of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA, USA.
Michelle BarrackDepartment of Family and Consumer Sciences, California State University Long Beach, Long Beach, CA, USA.
Elizabeth JoyIntermountain Healthcare, Salt Lake City, USA.
Aurelia NattivDepartment of Sports Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Mark HutchinsonDepartment of Orthopedics and Sports Medicine, University of Illinois Chicago, Chicago, IL, USA.
Madhusmita MisraDivision of Pediatric Endocrinology, Massachusetts General Hospital, Boston, MA, USA.
Nancy I WilliamsDepartment of Kinesiology, Pennsylvania State University, University Park, PA, 16802, USA. niw1@psu.edu.
Pennsylvania State University · USCalifornia State University, Long Beach · USHenry M. Jackson Foundation · USIntermountain Healthcare · USMassachusetts General Hospital · USUniversity of California, Los Angeles · USUniversity of Illinois Chicago · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Energy status plays a key role in the health of athletes and exercising individuals. Energy deficiency/low energy availability (EA), referring to a state in which insufficient energy intake and/or excessive exercise energy expenditure has resulted in compensatory metabolic adaptations to conserve fuel, can affect numerous physiological systems in women and men. The Female Athlete Triad, Male Athlete Triad, and Relative Energy Deficiency in Sport (RED-S) models conceptualize the effects of energy deficiency in athletes, and each model has strengths and limitations. For instance, the Female Athlete Triad model depicts relationships between low EA, reproductive, and bone health, underpinning decades of experimental evidence, but may be perceived as limited in scope, while the more recent RED-S model proposes a wider range of potential health effects of low EA, though many model components require more robust scientific justification. This critical review summarizes current evidence regarding the effects of energy deficiency on athlete health by addressing the quality of the underlying science, the strengths and limitations of each model, and highlighting areas where future research is needed to advance the field. With the health and wellness of athletes and exercising individuals as the overarching priority, we conclude with specific steps that will help focus future research on the Female and Male Athlete Triad and RED-S, and encourage all researchers, clinicians, and practitioners to collaborate to support the common goal of promoting the highest quality science and evidence-based medicine in pursuit of the advancement of athletes' health, well-being, and performance.

Indexed as

Female Athlete Triad SyndromeRelative Energy Deficiency in SportAthletesBone and BonesEnergy MetabolismFemaleHumansMale

Identifiers

PMID34665451
OpenAlexW3206462714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.