Evidence map›Paper›PMID 34665375›Full record

ArticleMetabolic brain disease2021

The role of carbonic anhydrase III and autophagy in type 2 diabetes with cardio-cerebrovascular disease.

Xiao-Ming Zhang, Ying-Hong Tao, Xiu-Ling Zhou, Xi-Liang Shang, Xiao-Bo Gong, Ying-Chao Liu, Yan-Yan Huang, Gang Chen, Zhong-Yu Yu, Jian-Tao Wang and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolic brain disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Role of Necroptosis and Neuroinflammation in CSVD-Associated Cognitive Decline in db/db Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  2. Article
  3. Article
  4. Emerging biomarkers for the detection of cardiovascular diseases.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Xiao-Ming ZhangGeriatrics Department and National Clinical Research Center for Aging and Medicine, Huashan Hospital, and Institutes of Brain Science, Fudan University, Shanghai, 200040, China.
Ying-Hong TaoDepartment of Medical Examination Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xiu-Ling ZhouDepartment of Ultrasonics, Huashan Hospital, Fudan Univesity, Shanghai, 200040, China.
Xi-Liang ShangDepartment of Sport Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xiao-Bo GongDepartment of Engineering Mechanics, School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Ying-Chao LiuDepartment of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China.
Yan-Yan HuangGeriatrics Department and National Clinical Research Center for Aging and Medicine, Huashan Hospital, and Institutes of Brain Science, Fudan University, Shanghai, 200040, China.
Gang ChenGeriatrics Department and National Clinical Research Center for Aging and Medicine, Huashan Hospital, and Institutes of Brain Science, Fudan University, Shanghai, 200040, China.
Zhong-Yu YuGeriatrics Department and National Clinical Research Center for Aging and Medicine, Huashan Hospital, and Institutes of Brain Science, Fudan University, Shanghai, 200040, China.
Jian-Tao WangGeriatrics Department and National Clinical Research Center for Aging and Medicine, Huashan Hospital, and Institutes of Brain Science, Fudan University, Shanghai, 200040, China.
Zun-Guo DuDepartment of Pathology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Guo-Feng WuDepartment of Emergency Neurology, Guiyang Medical University, Guiyang, 550004, China.
Yu ZhangGeriatrics Department and National Clinical Research Center for Aging and Medicine, Huashan Hospital, and Institutes of Brain Science, Fudan University, Shanghai, 200040, China. zy_huashan@163.com.
Jing-Chun GuoGeriatrics Department and National Clinical Research Center for Aging and Medicine, Huashan Hospital, and Institutes of Brain Science, Fudan University, Shanghai, 200040, China. jingchunguo@shmu.edu.cn.
Hou-Guang ZhouGeriatrics Department and National Clinical Research Center for Aging and Medicine, Huashan Hospital, and Institutes of Brain Science, Fudan University, Shanghai, 200040, China. zhg7376@163.com.
Fudan University · CNHuashan Hospital · CNGuiyang Medical University · CNShandong University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases among the elderly people. The T2DM increases the risk of cardio-cerebrovascular disease (CCD), and the main pathological change of the CCD is atherosclerosis (AS). Meanwhile, the carbonic anhydrases (CAs) are involved in the formation and progression of plaques in AS. However, the exact physiological mechanism of carbonic anhydrase III (CAIII) has not been clear yet, and there are also no correlation study between CAIII protein and T2DM with CCD. The 8-week old diabetic mice (db/db

Indexed as

Carbonic Anhydrase IIICerebrovascular DisordersDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2AnimalsAutophagyMiceCarbonic Anhydrase IIIAutophagyCarbonic anhydraseIIICardio-cerebrovascular diseaseType 2 diabetes

Identifiers

PMID34665375
PMCPMC8580918
OpenAlexW3168176002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.