Evidence map›Paper›PMID 34665315›Full record

ArticleEuropean radiology2022

An MRI-based radiomics-clinical nomogram for the overall survival prediction in patients with hypopharyngeal squamous cell carcinoma: a multi-cohort study.

Juan Chen, Shanhong Lu, Yitao Mao, Lei Tan, Guo Li, Yan Gao, Pingqing Tan, Donghai Huang, Xin Zhang, Yuanzheng Qiu and 1 more

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In one paragraph

Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. An MRI-based radiomics nomogram for detecting cervical esophagus invasion in hypopharyngeal squamous cell carcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Juan Chen *Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.
Shanhong Lu *Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.
Yitao MaoDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Lei TanCollege of Computer and Information Engineering, Hunan University of Technology and Business, Changsha, 410205, Hunan, China.
Guo LiDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.
Yan GaoDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.
Pingqing TanDepartment of Head and Neck Surgery, The Affiliated Tumor Hospital of Xiangya Medical School, Hunan Cancer Hospital, Central South University, Changsha, 410013, Hunan, China.
Donghai HuangDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.
Xin ZhangDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.
Yuanzheng QiuDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. xyqyz@csu.edu.cn.
Yong LiuDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. liuyongent@csu.edu.cn.

Funding

Huxiang Young Talent Project 2018RS3024National Key Research and Development Program of China 2020YFC1316900National Key Research and Development Program of China 2020YFC1316901National Natural Science Foundation of China 81602684National Natural Science Foundation of China 81772903National Natural Science Foundation of China 81773243National Natural Science Foundation of China 81974424National Natural Science Foundation of China 82073009, 81874133Natural Science Foundation of Hunan Province 2017JJ3488Natural Science Foundation of Hunan Province 2018JJ2630Natural Science Foundation of Hunan Province 2019JJ40481Natural Science Foundation of Hunan Province 2019JJ50944Young Scientist Research Fund of Xiangya Hospital 2018Q019
6 · The paper itself

Abstract

objectiveTo explore whether radiomics features extracted from pre-treatment magnetic resonance imaging (MRI) can predict the overall survival (OS) in patients with hypopharyngeal squamous cell carcinoma.

methodsA total of 190 patients with hypopharyngeal squamous cell carcinoma were eligibly enrolled from two institutions. Radiomics features were extracted from contrast-enhanced axial T1-weighted (CE-T1WI) sequence. The least absolute shrinkage selection operator (LASSO) algorithm was applied to establish a radiomics score correlated with OS. Multivariate logistic regression analysis was applied to determine the independent risk factors, which was combined with radiomics score to build the final radiomics nomogram.

resultsA radiomics score with 6 CE-T1WI features for OS prediction was constructed and validated; its integration with specific clinicopathologic factors (N stage) showed a better prediction performance in the training, internal validation, and external validation cohorts (C-index 0.78, 0.75, and 0.75). Calibration curves determined a good agreement between the predicted and actual overall survival.

conclusionsThe radiomics-clinical nomogram and radiomics score might be non-invasive and reliable methods for the risk stratification in patients with hypopharyngeal squamous cell carcinoma. KEY POINTS: • An MRI-based radiomics model was constructed to evaluate of OS in patients with hypopharyngeal squamous cell carcinoma. • A radiomics-clinical nomogram that combined radiomics features and clinical characteristics was established. • Multi-cohort study validated the predictive performance of the radiomics-clinical nomogram to stratify patients with high risk in clinical practice.

Indexed as

Head and Neck NeoplasmsNomogramsCohort StudiesHumansMagnetic Resonance ImagingRetrospective StudiesSquamous Cell Carcinoma of Head and NeckHypopharyngeal squamous cell carcinomaMagnetic resonance imagingNomogramPrognosisRadiomics

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.