Evidence map›Paper›PMID 34665288›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2022

In premenopausal women with idiopathic osteoporosis, lower bone formation rate is associated with higher body fat and higher IGF-1.

T G Goetz, N Nair, S Shiau, R R Recker, J M Lappe, D W Dempster, H Zhou, B Zhao, X Guo, W Shen and 6 more

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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Association between serum insulin-like growth factor 1 and osteoporosis risk in Parkinson's disease: a cross-sectional study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

T G GoetzColumbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.
N NairDepartment of Medicine, Columbia University Vagelos College of Physicians & Surgeons, NY, New York, USA.
S ShiauDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA.
R R ReckerDepartment of Medicine, Creighton University Medical Center, Omaha, NE, USA.
J M LappeDepartment of Medicine, Creighton University Medical Center, Omaha, NE, USA.
D W DempsterDepartment of Pathology and Cell Biology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.
H ZhouRegional Bone Center, Helen Hayes Hospital, West Haverstraw, NY, USA.
B ZhaoDepartment of Radiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.
X GuoDepartment of Radiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.
W ShenDepartment of Pediatrics, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.
T L NickolasDepartment of Medicine, Columbia University Vagelos College of Physicians & Surgeons, NY, New York, USA.
M Kamanda-KossehDepartment of Medicine, Columbia University Vagelos College of Physicians & Surgeons, NY, New York, USA.
M BucovskyDepartment of Medicine, Columbia University Vagelos College of Physicians & Surgeons, NY, New York, USA.
J StubbyDepartment of Medicine, Creighton University Medical Center, Omaha, NE, USA.
E ShaneDepartment of Medicine, Columbia University Vagelos College of Physicians & Surgeons, NY, New York, USA.
A CohenDepartment of Medicine, Columbia University Vagelos College of Physicians & Surgeons, NY, New York, USA. ac1044@columbia.edu.ORCID http://orcid.org/0000-0002-0641-5747
Columbia University · USCHI Health Creighton University Medical Center - Bergan Mercy · USColumbia University Irving Medical Center · USHelen Hayes Hospital · USRutgers, The State University of New Jersey · US

Funding

RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Teriparatide for Idiopathic Osteoporosis in Premenopausal Women: A Phase 2 StudyR01FD003902 · FDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COHEN, ADI, SHANE, ELIZABETH J · 2011 to 2019
$2.8M
IGF-1, bone turnover and response to teriparatide in premenopausal women with IOPR03AR064016 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COHEN, ADI · 2013 to 2015
$244k
FDA HHS R01 FD003902NIAMS NIH HHS R03 AR064016NIDDK NIH HHS P30 DK026687
6 · The paper itself

Abstract

We examined serum IGF-1 in premenopausal IOP, finding relationships that were opposite to those expected: higher IGF-1 was associated with lower bone formation and higher body fat, and lower BMD response to teriparatide. These paradoxical relationships between serum IGF-1, bone, and fat may contribute to the mechanism of idiopathic osteoporosis in premenopausal women.

introductionPremenopausal women with idiopathic osteoporosis (IOP) have marked deficits in bone microarchitecture but variable bone remodeling. We previously reported that those with low tissue-level bone formation rate (BFR) are less responsive to teriparatide and have higher serum IGF-1, a hormone anabolic for osteoblasts and other tissues. The IGF-1 data were unexpected because IGF-1 is low in other forms of low turnover osteoporosis-leading us to hypothesize that IGF-1 relationships are paradoxical in IOP. This study aimed to determine whether IOP women with low BFR have higher IGF-1 and paradoxical IGF-1 relationships in skeletal and non-skeletal tissues, and whether IGF-1 and the related measures predict teriparatide response.

methodsThis research is an ancillary study to a 24 month clinical trial of teriparatide for IOP. Baseline assessments were related to trial outcomes: BMD, bone remodeling. SUBJECTS: Premenopausal women with IOP(n = 34); bone remodeling status was defined by baseline cancellous BFR/BS on bone biopsy. MEASURES: Serum IGF-1 parameters, compartmental adiposity (DXA, CT, MRI), serum hormones, and cardiovascular-risk-markers related to fat distribution.

resultsAs seen in other populations, lower BFR was associated with higher body fat and poorer teriparatide response. However, in contrast to observations in other populations, low BFR, higher body fat, and poorer teriparatide response were all related to higher IGF-1: IGF-1 Z-score was inversely related to BFR at all bone surfaces (r =  - 0.39 to - 0.46; p < 0.05), directly related to central fat (p = 0.05) and leptin (p = 0.03). IGF-1 inversely related to 24 month hip BMD %change (r =  - 0.46; p = 0.01).

conclusionsParadoxical IGF-1 relationships suggest that abnormal or atypical regulation of bone and fat may contribute to osteoporosis mechanisms in premenopausal IOP.

Indexed as

Bone Density Conservation AgentsOsteoporosisAdipose TissueBone DensityFemaleHumansInsulin-Like Growth Factor IOsteogenesisTeriparatideBone Density Conservation AgentsInsulin-Like Growth Factor ITeriparatideBody compositionBone biopsyBone turnover markersMarrow adiposityPremenopausal osteoporosisTeriparatide

Identifiers

PMID34665288
PMCPMC9927557
OpenAlexW3207267715

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.