Evidence map›Paper›PMID 34665280›Full record

ArticleCellular and molecular life sciences : CMLS2021

Extracellular vesicle release and uptake by the liver under normo- and hyperlipidemia.

Krisztina Németh, Zoltán Varga, Dorina Lenzinger, Tamás Visnovitz, Anna Koncz, Nikolett Hegedűs, Ágnes Kittel, Domokos Máthé, Krisztián Szigeti, Péter Lőrincz and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 43 citations in OpenAlex.

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  20. Role of Extracellular Vesicles in Liver Diseases.Life (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Krisztina NémethDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.ORCID http://orcid.org/0000-0002-3825-2137
Zoltán VargaResearch Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, Budapest, Hungary.ORCID http://orcid.org/0000-0002-5741-2669
Dorina LenzingerDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.ORCID http://orcid.org/0000-0003-0270-7985
Tamás VisnovitzDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.ORCID http://orcid.org/0000-0002-7962-5083
Anna KonczDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Nikolett HegedűsDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Ágnes KittelEötvös Loránd Research Network, Institute of Experimental Medicine, Budapest, Hungary.ORCID http://orcid.org/0000-0002-6888-7731
Domokos MáthéDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.ORCID http://orcid.org/0000-0001-7343-0413
Krisztián SzigetiDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.ORCID http://orcid.org/0000-0002-0828-9828
Péter LőrinczDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.ORCID http://orcid.org/0000-0001-7374-667X
Clodagh O'NeillDiscipline of Surgery, National University of Ireland, Lambe Institute for Translational Research, Galway, Ireland.
Róisín DwyerDiscipline of Surgery, National University of Ireland, Lambe Institute for Translational Research, Galway, Ireland.ORCID http://orcid.org/0000-0002-5854-0339
Zhonglin LiuDepartment of Medical Imaging, University of Arizona, Tucson, AZ, USA.ORCID http://orcid.org/0000-0001-8259-9042
Edit I Buzás *Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.ORCID http://orcid.org/0000-0002-3744-206X
Viola Tamási *Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary. viola.tamasi@gmail.com.ORCID http://orcid.org/0000-0001-7419-5603
Semmelweis University · HUOllscoil na Gaillimhe – University of Galway · IEBanner - University Medical Center Tucson · USEötvös Loránd University · HUHUN-REN Institute of Experimental Medicine · HU

Funding

CENTER FOR GAMMA RAY IMAGINGP41EB002035 · NIBIB · UNIVERSITY OF ARIZONA · PI BARRETT, HARRISON H, FURENLID, LARS R · 2003 to 2018
$17.7M
horizon 2020 739593horizon 2020 H2020-MSCA-ITN-2017-722148 TRAIN EVinnovációs és technológiai minisztérium ÚNKP-19-4-SE-09innovációs és technológiai minisztérium ÚNKP-20-5 Bolyai+ New National Excellence Programmagyar tudományos akadémia János Bolyai Research Scholarshipmagyar tudományos akadémia PPD-222/2018nemzeti kutatási fejlesztési és innovációs hivatal FIKP Therapeutic Thematic Programmenemzeti kutatási fejlesztési és innovációs hivatal NVKP_16-1-2016-0017nemzeti kutatási fejlesztési és innovációs hivatal OTKA K120237nemzeti kutatási fejlesztési és innovációs hivatal VEKOP-2.3.2-16-2017-000002nemzeti kutatási fejlesztési és innovációs hivatal VEKOP-2.3.3-15-2017-00016NIBIB NIH HHS P41 EB002035NIBIB NIH HHS P41EB002035
6 · The paper itself

Abstract

Liver plays a central role in elimination of circulating extracellular vesicles (EVs), and it also significantly contributes to EV release. However, the involvement of the different liver cell populations remains unknown. Here, we investigated EV uptake and release both in normolipemia and hyperlipidemia. C57BL/6 mice were kept on high fat diet for 20-30 weeks before circulating EV profiles were determined. In addition, control mice were intravenously injected with

Indexed as

Disease Models, AnimalAnimalsDiet, High-FatExtracellular VesiclesHepatocytesHyperlipidemiasLiverMaleMiceMice, Inbred C57BLExtracellular particlesExtracellular vesicleHepatocyteKupffer cellLiver sinusoidal endothelial cells

Identifiers

PMID34665280
PMCPMC8629784
OpenAlexW3206043696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.