Evidence map›Paper›PMID 34665257›Full record

ReviewEmerging topics in life sciences2021

Graph representation learning for structural proteomics.

Romanos Fasoulis, Georgios Paliouras, Lydia E Kavraki

Open access · greenAbstract readReview
In one paragraph

Review in Emerging topics in life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Predicting Protein-Protein Interactions from Machine-Learned Representations.Advances in experimental medicine and biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Graph Neural Network-Based Approaches for Protein Function Prediction.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Romanos FasoulisDepartment of Computer Science, Rice University, Houston, TX, U.S.A.ORCID 0000-0001-7106-6689
Georgios PaliourasInstitute of Informatics and Telecommunications, NCSR Demokritos, Athens, Greece.ORCID 0000-0001-9629-2367
Lydia E KavrakiDepartment of Computer Science, Rice University, Houston, TX, U.S.A.ORCID 0000-0003-0699-8038
National Centre of Scientific Research "Demokritos" · GR

Funding

PROTEAN-CR: Proteomics Toolkit for Ensemble Analysis in Cancer ResearchU01CA258512 · NCI · RICE UNIVERSITY · PI KAVRAKI, LYDIA E., LIZEE, GREGORY A · 2021 to 2023
$1.2M
NCI NIH HHS U01 CA258512
6 · The paper itself

Abstract

The field of structural proteomics, which is focused on studying the structure-function relationship of proteins and protein complexes, is experiencing rapid growth. Since the early 2000s, structural databases such as the Protein Data Bank are storing increasing amounts of protein structural data, in addition to modeled structures becoming increasingly available. This, combined with the recent advances in graph-based machine-learning models, enables the use of protein structural data in predictive models, with the goal of creating tools that will advance our understanding of protein function. Similar to using graph learning tools to molecular graphs, which currently undergo rapid development, there is also an increasing trend in using graph learning approaches on protein structures. In this short review paper, we survey studies that use graph learning techniques on proteins, and examine their successes and shortcomings, while also discussing future directions.

Indexed as

Machine LearningProteomicsDatabases, ProteinLearningProteinsProteinsdeep learninggraph learninggraphsmachine learningprotein structureproteomics

Identifiers

PMID34665257
PMCPMC8786289
OpenAlexW3207815566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.