Evidence map›Paper›PMID 34665233›Full record

ArticleTranslational vision science & technology2021

Challenges Associated With Ellipsoid Zone Intensity Measurements Using Optical Coherence Tomography.

Karen E Lee, Heather Heitkotter, Joseph Carroll

Open access · goldAbstract read
In one paragraph

Article in Translational vision science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  15. Intensity adaptive optics.Light, science & applications · 2025
    Article
  16. Review
  17. Article
  18. OCT Biomarkers in a Cohort of Patients WithJournal of ophthalmology · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Karen E LeeMedical College of Wisconsin, Milwaukee, WI, USA.
Heather HeitkotterCell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
Joseph CarrollCell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
Medical College of Wisconsin · US

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
Assessing Photoreceptor Structure and Function in Normal and Diseased RetinaeR01EY017607 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI Joseph Carroll · 2008 to 2026
$8.3M
VISION RES LAB: HERPETIC KERATIC, CORE PIGMENT GENES, RETINITIS PIGMENTOSAC06RR016511 · NCRR · MEDICAL COLLEGE OF WISCONSIN · PI DUNN, MICHAEL J · 2002 to 2002
$1.4M
Multimodal assessment of photoreceptor structure and function in retinal traumaF31EY033204 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI HEITKOTTER, HEATHER · 2021 to 2023
$118k
NCATS NIH HHS UL1 TR001436NCRR NIH HHS C06 RR016511NEI NIH HHS F31 EY033204NEI NIH HHS R01 EY017607
6 · The paper itself

Abstract

Translational Relevance: Qualitative evaluation of the ellipsoid zone band on optical coherence tomography is a valuable clinical tool for assessing photoreceptor structure, though more quantitative metrics are emerging. Awareness of the challenges involved in interpreting quantitative metrics is important for their clinical translation.

Indexed as

Photoreceptor CellsTomography, Optical CoherenceVisual Acuity

Identifiers

PMID34665233
PMCPMC8543396
OpenAlexW3205350051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.