ArticleEuropean heart journal2021
Prognostic value of comprehensive intracoronary physiology assessment early after heart transplantation.
Article in European heart journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Percutaneous coronary intervention in cardiac allograft vasculopathy: From lesion selection to longitudinal graft management.JHLT open · 2026Review
- From the Bench to the Bedside and Back: Contemporary Applications of Basic Science to Innovations in Heart Transplantation.The Canadian journal of cardiology · 2026Review
- Invasive Coronary Physiology Assessment for Detecting Microcirculatory Dysfunction in Heart Transplant Recipients.Annals of transplantation · 2025Article
- The Proteome Profile of Stress Test Assessed Cardiovascular Disease Risk-Prone Diabetic Subjects.Journal of cardiovascular translational research · 2025Article
- Can the grading of mild cardiac allograft vasculopathy be further refined? An angiographic and physiologic assessment of heart transplant recipients with ISHLT CAV 1.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Article
- Repeatability and Correlation of Coronary Physiology Indices Measured With Bolus and Continuous Thermodilution.Circulation. Cardiovascular interventions · 2025Article
- Microcirculation and intravascular imaging assessment in heart transplant recipients for detection of cardiac allograft vasculopathy: a pilot study.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025Article
- Elevated Donor-Derived Cell-Free DNA Levels Are Associated With Reduced Myocardial Blood Flow but Not Angiographic Cardiac Allograft Vasculopathy: The EVIDENT Study.Circulation. Heart failure · 2025Article
- Cardiac Allograft Vasculopathy: A Focus on Advances in Diagnosis and Management.Methodist DeBakey cardiovascular journal · 2025Review
- Added prognostic value of visually estimated coronary artery calcium among heart transplant recipients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Article
- Quantitative flow ratio computed from invasive coronary angiography as a predictor for cardiac allograft vasculopathy after cardiac transplant.The international journal of cardiovascular imaging · 2024Article
- Practical Application of Coronary Physiologic Assessment: Asia-Pacific Expert Consensus Document: Part 2.JACC. Asia · 2023Review
- Evaluation of perivascular fat attenuation with coronary CT angiography in cardiac transplantation patients: an imaging biomarker candidate for prediction of cardiac mortality and re-transplantation.European radiology · 2023Article
- Effects of high-intensity interval training on cardiac remodelling, function and coronary microcirculation in de novo heart transplant patients: a substudy of the HITTS randomised controlled trial.BMJ open sport & exercise medicine · 2023Article
- Noninvasive Physiologic Assessment of Cardiac Allograft Vasculopathy Is Prognostic for Post-Transplant Events.Journal of the American College of Cardiology · 2022Article
- Invasive Coronary Physiology in Heart Transplant Recipients: State-of-the-Art Review.Journal of the Society for Cardiovascular Angiography & InterventionsReview
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19 authors at 7 institutions in 6 countries.
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Abstract
aimsWe evaluated the long-term prognostic value of invasively assessing coronary physiology after heart transplantation in a large multicentre registry. METHODS AND
resultsComprehensive intracoronary physiology assessment measuring fractional flow reserve (FFR), the index of microcirculatory resistance (IMR), and coronary flow reserve (CFR) was performed in 254 patients at baseline (a median of 7.2 weeks) and in 240 patients at 1 year after transplantation (199 patients had both baseline and 1-year measurement). Patients were classified into those with normal physiology, reduced FFR (FFR ≤ 0.80), and microvascular dysfunction (either IMR ≥ 25 or CFR ≤ 2.0 with FFR > 0.80). The primary outcome was the composite of death or re-transplantation at 10 years. At baseline, 5.5% had reduced FFR; 36.6% had microvascular dysfunction. Baseline reduced FFR [adjusted hazard ratio (aHR) 2.33, 95% confidence interval (CI) 0.88-6.15; P = 0.088] and microvascular dysfunction (aHR 0.88, 95% CI 0.44-1.79; P = 0.73) were not predictors of death and re-transplantation at 10 years. At 1 year, 5.0% had reduced FFR; 23.8% had microvascular dysfunction. One-year reduced FFR (aHR 2.98, 95% CI 1.13-7.87; P = 0.028) and microvascular dysfunction (aHR 2.33, 95% CI 1.19-4.59; P = 0.015) were associated with significantly increased risk of death or re-transplantation at 10 years. Invasive measures of coronary physiology improved the prognostic performance of clinical variables (χ2 improvement: 7.41, P = 0.006). However, intravascular ultrasound-derived changes in maximal intimal thickness were not predictive of outcomes.
conclusionAbnormal coronary physiology 1 year after heart transplantation was common and was a significant predictor of death or re-transplantation at 10 years.
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