ArticleeLife2021
Finger somatotopy is preserved after tetraplegia but deteriorates over time.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Assessing MR-compatibility of somatosensory stimulation devices: A systematic review on testing methodologies.Frontiers in neuroscience · 2023Pooled it
- Simultaneous speech and gesture decoding for multimodal communication in paralysis.Nature neuroscience · 2026Article
- Distinct Neural Modes Carry Information About Attempted Grasp Timing and Force in the Sensorimotor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cutting a nerve of the hand alters the organization of digit maps in primary somatosensory cortex.Nature human behaviour · 2026Article
- Optimal location for gesture decoding in the sensorimotor cortex and implications for brain-computer interface research.NeuroImage · 2026Article
- Article
- TMS-Based Neurofeedback Training of Mental Finger Individuation Induces Neuroplastic Changes in the Sensorimotor System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Evoking stable and precise tactile sensations via multi-electrode intracortical microstimulation of the somatosensory cortex.Nature biomedical engineering · 2025Article
- Motor somatotopy impacts imagery strategy success in human intracortical brain-computer interfaces.Journal of neural engineering · 2025Article
- Soft Nanomembrane Sensor-Enabled Wearable Multimodal Sensing and Feedback System for Upper-Limb Sensory Impairment Assistance.ACS nano · 2025Article
- Distinguishing the activity of adjacent somatosensory nuclei within the brainstem using 3T fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathy.Nature communications · 2024Article
- A Roadmap for Implanting Electrode Arrays to Evoke Tactile Sensations Through Intracortical Stimulation.Human brain mapping · 2024Article
- Motor somatotopy impacts imagery strategy success in human intracortical brain-computer interfaces.medRxiv : the preprint server for health sciences · 2024Article
- The speech neuroprosthesis.Nature reviews. Neuroscience · 2024Review
- A roadmap for implanting microelectrode arrays to evoke tactile sensations through intracortical microstimulation.medRxiv : the preprint server for health sciences · 2024Article
- Performing a vibrotactile discrimination task modulates finger representations in primary somatosensory cortex.Journal of neurophysiology · 2023Article
- Tessellation of artificial touch via microstimulation of human somatosensory cortex.bioRxiv : the preprint server for biology · 2023Article
- S1 represents multisensory contexts and somatotopic locations within and outside the bounds of the cortical homunculus.Cell reports · 2023Article
- Integrated Neuroregenerative Techniques for Plasticity of the Injured Spinal Cord.Biomedicines · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies showed reorganised and/or altered activity in the primary sensorimotor cortex after a spinal cord injury (SCI), suggested to reflect abnormal processing. However, little is known about whether somatotopically specific representations can be activated despite reduced or absent afferent hand inputs. In this observational study, we used functional MRI and a (attempted) finger movement task in tetraplegic patients to characterise the somatotopic hand layout in primary somatosensory cortex. We further used structural MRI to assess spared spinal tissue bridges. We found that somatotopic hand representations can be activated through attempted finger movements in the absence of sensory and motor hand functioning, and no spared spinal tissue bridges. Such preserved hand somatotopy could be exploited by rehabilitation approaches that aim to establish new hand-brain functional connections after SCI (e.g. neuroprosthetics). However, over years since SCI the hand representation somatotopy deteriorated, suggesting that somatotopic hand representations are more easily targeted within the first years after SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.