ArticleeLife2021
Learning differentially shapes prefrontal and hippocampal activity during classical conditioning.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Entorhinal cortex represents task-relevant remote locations independently of CA1.Nature neuroscience · 2026Article
- Dentate gyrus and CA3 activity mediates light-tone second-order conditioning expression in mice.iScience · 2026Article
- A reliable and holistic approach to evaluating hearing and cognitive auditory processing in adult and aged companion dogs.Scientific reports · 2026Article
- Neuronal mismatch responses to auditory stimuli in the dorsal hippocampus of anesthetized rats.Communications biology · 2025Article
- Modulation of Hippocampal Sharp-Wave Ripples by Behavioral States and Body Movements in Head-Fixed Rodents.eNeuro · 2025Article
- Intra-individual comparison of appetitive trace and delay conditioning in humans across acquisition and extinction.Scientific reports · 2025Article
- Hippocampal Sharp-Wave Ripples Decrease during Physical Actions Including Consummatory Behavior in Immobile Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Entorhinal cortex represents task-relevant remote locations independent of CA1.bioRxiv : the preprint server for biology · 2024Article
- Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus.Nature communications · 2023Article
- Mixed representations of sound and action in the auditory midbrain.bioRxiv : the preprint server for biology · 2023Article
- Article
- Sustained Activity of Hippocampal Parvalbumin-Expressing Interneurons Supports Trace Eyeblink Conditioning in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The hearing hippocampus.Progress in neurobiology · 2022Review
- Contingent Amygdala Inputs Trigger Heterosynaptic LTP at Hippocampus-To-Accumbens Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Prefrontal projections to the nucleus reuniens signal behavioral relevance of stimuli during associative learning.Scientific reports · 2022Article
- Combining Cortical Voltage Imaging and Hippocampal Electrophysiology for Investigating Global, Multi-Timescale Activity Interactions in the Brain.International journal of molecular sciences · 2022Article
- Learning differentially shapes prefrontal and hippocampal activity during classical conditioning.eLife · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to use sensory cues to inform goal-directed actions is a critical component of behavior. To study how sounds guide anticipatory licking during classical conditioning, we employed high-density electrophysiological recordings from the hippocampal CA1 area and the prefrontal cortex (PFC) in mice. CA1 and PFC neurons undergo distinct learning-dependent changes at the single-cell level and maintain representations of cue identity at the population level. In addition, reactivation of task-related neuronal assemblies during hippocampal awake Sharp-Wave Ripples (aSWRs) changed within individual sessions in CA1 and over the course of multiple sessions in PFC. Despite both areas being highly engaged and synchronized during the task, we found no evidence for coordinated single cell or assembly activity during conditioning trials or aSWR. Taken together, our findings support the notion that persistent firing and reactivation of task-related neural activity patterns in CA1 and PFC support learning during classical conditioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.