Evidence map›Paper›PMID 34665011›Full record

ArticlemSystems2021

Microbiome Clusters Disclose Physiologic Variances in Dairy Cows Challenged by Calving and Lipopolysaccharides.

Johanna Tröscher-Mußotter, Johan S Saenz, Sandra Grindler, Jennifer Meyer, Susanne U Kononov, Beate Mezger, Daniel Borda-Molina, Jana Frahm, Sven Dänicke, Amélia Camarinha-Silva and 2 more

Abstract read
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
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  12. Article
  13. Colonization and development of the gut microbiome in calves.Journal of animal science and biotechnology · 2023
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Johanna Tröscher-MußotterHoLMiR-Hohenheim Center for Livestock Microbiome Research, University of Hohenheimgrid.9464.f, Stuttgart, Germany.ORCID 0000-0003-0600-3213
Johan S SaenzHoLMiR-Hohenheim Center for Livestock Microbiome Research, University of Hohenheimgrid.9464.f, Stuttgart, Germany.ORCID 0000-0002-7240-8561
Sandra GrindlerHoLMiR-Hohenheim Center for Livestock Microbiome Research, University of Hohenheimgrid.9464.f, Stuttgart, Germany.
Jennifer MeyerInstitute of Animal Nutrition, Friedrich-Loeffler-Institutgrid.417834.d, Federal Research Institute for Animal Health, Braunschweig, Germany.
Susanne U KononovInstitute of Animal Science, University of Hohenheimgrid.9464.f, Stuttgart, Germany.
Beate MezgerHoLMiR-Hohenheim Center for Livestock Microbiome Research, University of Hohenheimgrid.9464.f, Stuttgart, Germany.
Daniel Borda-MolinaInstitute of Animal Science, University of Hohenheimgrid.9464.f, Stuttgart, Germany.
Jana FrahmInstitute of Animal Nutrition, Friedrich-Loeffler-Institutgrid.417834.d, Federal Research Institute for Animal Health, Braunschweig, Germany.ORCID 0000-0003-1770-5229
Sven DänickeInstitute of Animal Nutrition, Friedrich-Loeffler-Institutgrid.417834.d, Federal Research Institute for Animal Health, Braunschweig, Germany.ORCID 0000-0002-4913-4726
Amélia Camarinha-SilvaHoLMiR-Hohenheim Center for Livestock Microbiome Research, University of Hohenheimgrid.9464.f, Stuttgart, Germany.ORCID 0000-0001-7814-6569
Korinna HuberHoLMiR-Hohenheim Center for Livestock Microbiome Research, University of Hohenheimgrid.9464.f, Stuttgart, Germany.
Jana SeifertHoLMiR-Hohenheim Center for Livestock Microbiome Research, University of Hohenheimgrid.9464.f, Stuttgart, Germany.ORCID 0000-0002-7690-8539

Funding

Deutsche Forschungsgemeinschaft (DFG) 202989534
6 · The paper itself

Abstract

Dairy cows respond individually to stressful situations, even under similar feeding and housing conditions. The phenotypic responsiveness might trace back to their microbiome and its interactions with the host. This long-term study investigated the effects of calving, lipopolysaccharide (LPS)-induced inflammation, and l-carnitine supplementation on fecal bacteria and metabolites, dairy cow milk production, health, energy metabolism, and blood metabolites. Fifty-four multiparous Holstein dairy cows were examined over a defined period of life (168 days). The obtained data allowed a holistic analysis combining microbiome data such as 16S rRNA amplicon sequencing and fecal targeted metabolome (188 metabolites) with host parameters. The conducted analyses allowed the definition of three enterotype-like microbiome clusters in dairy cows which could be linked to the community diversity and dynamics over time. The microbiome clusters were discovered to be treatment independent, governed by

Indexed as

Bifidobacteriumcalvingdairy cowlipopolysaccharidemetabolomemicrobiome clusterstransition

Identifiers

PMID34665011
PMCPMC8525563

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.