Evidence map›Paper›PMID 34664804›Full record

ArticleJournal of Korean medical science2021

Myocarditis-induced Sudden Death after BNT162b2 mRNA COVID-19 Vaccination in Korea: Case Report Focusing on Histopathological Findings.

Sangjoon Choi, SangHan Lee, Jeong-Wook Seo, Min-Ju Kim, Yo Han Jeon, Ji Hyun Park, Jong Kyu Lee, Nam Seok Yeo

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of Korean medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 4 pooled it
16.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 4 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. Pooled it
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  13. An Update on Myocarditis in Forensic Pathology.Diagnostics (Basel, Switzerland) · 2024
    Review
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  19. Arrhythmias after COVID-19 Vaccination: Have We Left All Stones Unturned?International journal of molecular sciences · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sangjoon ChoiDepartment of Forensic Medicine, Defense Institute of Forensic Science, Criminal Investigation Command, Ministry of National Defense, Seoul, Korea.ORCID https://orcid.org/0000-0003-2108-0575
SangHan LeeDepartment of Forensic Medicine, Defense Institute of Forensic Science, Criminal Investigation Command, Ministry of National Defense, Seoul, Korea. sanghan111@gmail.com.ORCID https://orcid.org/0000-0003-0390-3494
Jeong-Wook SeoDepartment of Pathology, Incheon Sejong Hospital, Incheon, Korea.ORCID https://orcid.org/0000-0003-0242-1805
Min-Ju KimDepartment of Pathology, Incheon Sejong Hospital, Incheon, Korea.ORCID https://orcid.org/0000-0003-3850-9892
Yo Han JeonDepartment of Forensic Medicine, Defense Institute of Forensic Science, Criminal Investigation Command, Ministry of National Defense, Seoul, Korea.ORCID https://orcid.org/0000-0002-0353-7255
Ji Hyun ParkDepartment of Forensic Medicine, Defense Institute of Forensic Science, Criminal Investigation Command, Ministry of National Defense, Seoul, Korea.ORCID https://orcid.org/0000-0002-1534-0070
Jong Kyu LeeDepartment of Forensic Medicine, Defense Institute of Forensic Science, Criminal Investigation Command, Ministry of National Defense, Seoul, Korea.ORCID https://orcid.org/0000-0002-0492-4417
Nam Seok YeoDepartment of Forensic Medicine, Defense Institute of Forensic Science, Criminal Investigation Command, Ministry of National Defense, Seoul, Korea.ORCID https://orcid.org/0000-0001-7254-6414
Ministry of National Defense · KRIncheon Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present autopsy findings of a 22-year-old man who developed chest pain 5 days after the first dose of the BNT162b2 mRNA vaccine and died 7 hours later. Histological examination of the heart revealed isolated atrial myocarditis, with neutrophil and histiocyte predominance. Immunohistochemical C4d staining revealed scattered single-cell necrosis of myocytes which was not accompanied by inflammatory infiltrates. Extensive contraction band necrosis was observed in the atria and ventricles. There was no evidence of microthrombosis or infection in the heart and other organs. The primary cause of death was determined to be myocarditis, causally-associated with the BNT162b2 vaccine.

Indexed as

AdultAutopsyBNT162 VaccineCOVID-19 VaccinesDeath, SuddenHumansMaleMyocarditisMyocardiumVaccinationBNT162 VaccineCOVID-19 VaccinesAdverse Event Following ImmunizationCoronavirus Disease 19mRNA VaccinesMyocarditisSudden Cardiac DeathVaccination

Identifiers

PMID34664804
PMCPMC8524235
OpenAlexW3206025668

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.