Evidence map›Paper›PMID 34664799›Full record

ArticleJournal of Korean medical science2021

Preclinical Evaluation of a Novel Polymer-free Everolimus-eluting Stent in a Mid-term Porcine Coronary Restenosis Model.

Kyung Hoon Cho, Myung Ho Jeong, Dae Sung Park, Moonki Kim, JungHa Kim, Jun-Kyu Park, Xiongyi Han, Dae Young Hyun, Min Chul Kim, Doo Sun Sim and 3 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Journal of Korean medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Kyung Hoon ChoDepartment of Cardiology, Chonnam National University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0002-0377-6352
Myung Ho JeongDepartment of Cardiology, Chonnam National University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0003-2424-810X
Dae Sung ParkCardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0002-9948-7546
Moonki KimCardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0002-7397-2236
JungHa KimCardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0003-3334-3432
Jun-Kyu ParkCGBio Co. Ltd., Seoul, Korea.ORCID https://orcid.org/0000-0002-1587-5673
Xiongyi HanDepartment of Cardiology, Chonnam National University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0002-8650-2954
Dae Young HyunDepartment of Cardiology, Chonnam National University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0002-0038-0125
Min Chul KimDepartment of Cardiology, Chonnam National University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0001-6026-1702
Doo Sun SimDepartment of Cardiology, Chonnam National University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0003-4162-7902
Young Joon HongDepartment of Cardiology, Chonnam National University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0003-0192-8161
Ju Han KimDepartment of Cardiology, Chonnam National University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0002-3186-0770
Youngkeun AhnDepartment of Cardiology, Chonnam National University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0003-2022-9366
Chonnam National University Hospital · KR

Funding

Chonnam National University Hospital Biomedical Research Institute BCRI-20075Korea Medical Device Development 202011A05-03Korea Medical Device Development 202015X08-01
6 · The paper itself

Abstract

backgroundTitanium dioxide films exhibit good biocompatibility and may be effective as drug-binding matrices for drug-eluting stents. We conducted a mid-term evaluation of a novel polymer-free everolimus-eluting stent using nitrogen-doped titanium dioxide film deposition (TIGEREVOLUTION

methodsTwenty-eight coronary arteries from 14 mini-pigs were randomly allocated to TIGEREVOLUTION

resultsQuantitative coronary analysis showed no significant differences in the pre-procedural, post-procedural, and 6-month lumen diameters between the groups. In the volumetric analysis of optical coherence tomography at 6 months, no significant differences were observed in stent volume, lumen volume, and percent area stenosis between the groups. There were no significant differences in injury score, inflammation score, or fibrin score between the groups, although the fibrin score was zero in the TIGEREVOLUTION

conclusionPreclinical evaluation, including optical coherence tomographic findings 6 months after stenting, demonstrated that the TIGEREVOLUTION

Indexed as

Drug-Eluting StentsAnimalsCoronary AngiographyCoronary RestenosisCoronary VesselsDisease Models, AnimalDrug Evaluation, PreclinicalEverolimusPolymersSwineSwine, MiniatureTitaniumTomography, Optical CoherenceEverolimusPolymersTitaniumtitanium dioxideDrug-eluting StentsOptical Coherence TomographyPolymersSwineTitanium Dioxide

Identifiers

PMID34664799
PMCPMC8524232
OpenAlexW3201391059

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.