Evidence map›Paper›PMID 34664594›Full record

ReviewNatural product reports2022

Recent strategies and tactics for the enantioselective total syntheses of cyclolignan natural products.

Rebekah G Reynolds, Huong Quynh Anh Nguyen, Jordan C T Reddel, Regan J Thomson

Abstract readReview
In one paragraph

Review in Natural product reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rebekah G ReynoldsDepartment of Chemistry, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA. r-thomson@northwestern.edu.ORCID 0000-0002-8723-2749
Huong Quynh Anh NguyenDepartment of Chemistry, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA. r-thomson@northwestern.edu.ORCID 0000-0002-9907-8275
Jordan C T ReddelDepartment of Chemistry, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA. r-thomson@northwestern.edu.
Regan J ThomsonDepartment of Chemistry, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA. r-thomson@northwestern.edu.ORCID 0000-0001-5546-4038

Funding

New Methods and Strategies for the Concise Synthesis of Bioactive Polycyclic MoleculesR01GM124089 · NIGMS · NORTHWESTERN UNIVERSITY · PI THOMSON, REGAN JAMES · 2018 to 2021
$1.2M
NIGMS NIH HHS R01 GM124089
6 · The paper itself

Abstract

Covering: 2000 to 2021Lignan natural products are found in many different plant species and possess numerous useful biological properties, such as anti-inflammatory, antiviral, antioxidant, antibacterial, and antitumor activities. Their utility in both traditional and conventional medicine, coupled with their structural diversity has made them popular synthetic targets over many decades. This review specifically addresses the cyclolignan subclass of the family, which possess both a C8-C8' and a C2-C7' linkage between two different phenylpropene units. We present a comprehensive overview of the diverse strategies employed by chemists to achieve enantioselective total syntheses of cyclolignans covering: 2000 to 2021.

Indexed as

Biological ProductsAntiviral AgentsPlantsStereoisomerismAntiviral AgentsBiological Products

Identifiers

PMID34664594
PMCPMC8957534

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.