Evidence map›Paper›PMID 34664567›Full record

ArticleBiomaterials science2021

Biomimetic polydopamine-laced hydroxyapatite collagen material orients osteoclast behavior to an anti-resorptive pattern without compromising osteoclasts' coupling to osteoblasts.

Lufei Wang, Tai-Hsien Wu, Xiangxiang Hu, Jie Liu, Di Wu, Patricia A Miguez, John Timothy Wright, Shaoping Zhang, Jen-Tsan Chi, Henry C Tseng and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Lufei WangDivision of Oral and Craniofacial Health Sciences, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-4691-2665
Tai-Hsien WuDivision of Orthodontics, The Ohio State University College of Dentistry, Columbus, OH, USA. ko.367@osu.edu.
Xiangxiang HuDivision of Oral and Craniofacial Health Sciences, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, USA.
Jie LiuDivision of Orthodontics, The Ohio State University College of Dentistry, Columbus, OH, USA. ko.367@osu.edu.
Di WuDivision of Oral and Craniofacial Health Sciences, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, USA.
Patricia A MiguezDivision of Comprehensive Oral Health, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, USA.
John Timothy WrightDivision of Pediatric and Public Health, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, USA.
Shaoping ZhangDepartment of Periodontics, University of Iowa College of Dentistry, Iowa City, IA, USA.
Jen-Tsan ChiDepartment of Molecular Genetics and Microbiology, Center for Genomics and Computational Biology, Duke University Medical Center, Durham, NC, USA.
Henry C TsengDuke Eye Center and Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
Ching-Chang KoDivision of Orthodontics, The Ohio State University College of Dentistry, Columbus, OH, USA. ko.367@osu.edu.
University of North Carolina at Chapel Hill · USThe Ohio State University · USDuke Medical Center · USUniversity of Iowa · US

Funding

Engineering novel bio-inspired materials for stem-cell mediated bone regenerationR01DE022816 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KO, CHING-CHANG · 2014 to 2018
$2.0M
NIDCR NIH HHS R01 DE022816
6 · The paper itself

Abstract

Polydopamine-assisted modification for bone substitute materials has recently shown great application potential in bone tissue engineering due to its excellent biocompatibility and adhesive properties. A scaffold material's impact on osteoclasts is equally as important as its impact on osteoblasts when considering tissue engineering for bone defect repair, as healthy bone regeneration requires an orchestrated coupling between osteoclasts and osteoblasts. How polydopamine-functionalized bone substitute materials modulate the activity of osteoblast lineage cells has been extensively investigated, but much less is known about their impact on osteoclasts. Moreover, most of the polydopamine-functionalized materials would need to additionally load a biomolecule to exert the modulation on osteoclast activity. Herein, we demonstrated that our biomimetic polydopamine-laced hydroxyapatite collagen (PDHC) scaffold material, which does not need to load additional bioactive agent, is sufficiently able to modulate osteoclast activity

Indexed as

Bone ResorptionOsteoclastsBiomimeticsCell DifferentiationCollagenDurapatiteHumansIndolesOsteoblastsPolymersCollagenDurapatiteIndolespolydopaminePolymers

Identifiers

PMID34664567
PMCPMC10547016
OpenAlexW3207961926

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.