Evidence map›Paper›PMID 34664550›Full record

ArticleeLife2021

The structure of behavioral variation within a genotype.

Zachary Werkhoven, Alyssa Bravin, Kyobi Skutt-Kakaria, Pablo Reimers, Luisa F Pallares, Julien Ayroles, Benjamin L de Bivort

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Article
  3. Entropy (Basel, Switzerland) · 2026
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  10. Review
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  13. Uncovering multiscale structure in the variability of larval zebrafish navigation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Article
  15. Spatiotemporal dynamics of locomotor decisions inbioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. NAPS: Integrating pose estimation and tag-based tracking.Methods in ecology and evolution · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zachary WerkhovenCenter for Brain Science and Department of Organismic and Evolutionary Biology, Cambridge, United States.ORCID 0000-0003-0611-5864
Alyssa BravinCenter for Brain Science and Department of Organismic and Evolutionary Biology, Cambridge, United States.
Kyobi Skutt-KakariaCenter for Brain Science and Department of Organismic and Evolutionary Biology, Cambridge, United States.
Pablo ReimersCenter for Brain Science and Department of Organismic and Evolutionary Biology, Cambridge, United States.
Luisa F PallaresDepartment of Ecology and Evolutionary Biology and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, United States.ORCID 0000-0001-6547-1901
Julien AyrolesCenter for Brain Science and Department of Organismic and Evolutionary Biology, Cambridge, United States.ORCID 0000-0001-8729-0511
Benjamin L de BivortCenter for Brain Science and Department of Organismic and Evolutionary Biology, Cambridge, United States.ORCID 0000-0001-6165-7696

Funding

A path to personalized phenotypic prediction: unlocking the context-dependency of allelic effectsR35GM124881 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Julien Ayroles · 2017 to 2026
$3.7M
A Modular Automated Platform for Large-scale Drosophila Experiments and HandlingR43MH119092 · NIMH · FLYSORTER, LLC · PI ZUCKER, DAVID · 2018 to 2018
$348k
Howard Hughes Medical InstituteNIGMS NIH HHS R35 GM124881NIMH NIH HHS R43 MH119092
6 · The paper itself

Abstract

Individual animals vary in their behaviors. This is true even when they share the same genotype and were reared in the same environment. Clusters of covarying behaviors constitute behavioral syndromes, and an individual's position along such axes of covariation is a representation of their personality. Despite these conceptual frameworks, the structure of behavioral covariation within a genotype is essentially uncharacterized and its mechanistic origins unknown. Passing hundreds of inbred

Indexed as

Behavior, AnimalGenotypeAnimalsDrosophila melanogastercovariationD. melanogastergeneticsgenomicshigh-throughput behaviorinvdividualityneural circuitsneurosciencepersonalitytranscriptomics

Identifiers

PMID34664550
PMCPMC8526060

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.